Polygenic risk scores for alcohol involvement relate to brain structure in substance-naïve children: Results from the ABCD study.

Genes, Brain, and Behavior
Alexander S HatoumRyan Bogdan

Abstract

Brain imaging-derived structural correlates of alcohol involvement have largely been speculated to arise as a consequence of alcohol exposure. However, they may also reflect predispositional risk. In substance naïve children of European ancestry who completed the baseline session of the Adolescent Brain Cognitive Development (ABCD) Study (n = 3013), mixed-effects models estimated whether polygenic risk scores (PRS) for problematic alcohol use (PAU-PRS) and drinks per week (DPW-PRS) are associated with magnetic resonance imaging-derived brain structure phenotypes (i.e., total and regional: cortical thickness, surface area and volume; subcortical volume; white matter volume, fractional anisotropy, mean diffusivity). Follow-up analyses evaluated whether any identified regions were also associated with polygenic risk among substance naïve children of African ancestry (n = 898). After adjustment for multiple testing correction, polygenic risk for PAU was associated with lower volume of the left frontal pole and greater cortical thickness of the right supramarginal gyrus (|βs| > 0.009; ps < 0.001; psfdr  < 0.046; r2 s < 0.004). PAU PRS and DPW PRS showed nominally significant associations with a host of other regional brain structure...Continue Reading

References

Sep 5, 2002·The American Journal of Drug and Alcohol Abuse·Glenn D Walters
Oct 3, 2002·The American Journal of Psychiatry·Rita Z Goldstein, Nora D Volkow
Feb 24, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cornelia StoeckelJoseph T Devlin
Mar 27, 2013·Neurology·Richard C GershonCindy J Nowinski
Aug 30, 2014·Psychological Medicine·B VerhulstK S Kendler
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Rosa YuSuzanne M de la Monte
Jan 28, 2016·The New England Journal of Medicine·Nora D VolkowA Thomas McLellan
Feb 28, 2016·BMC Genomics·James W BaurleyAndrew W Bergen
Apr 4, 2017·American Journal of Human Genetics·Alicia R MartinEimear E Kenny
Oct 21, 2017·Developmental Cognitive Neuroscience·Nora D VolkowSusan R B Weiss
Mar 24, 2018·Developmental Cognitive Neuroscience·B J CaseyUNKNOWN ABCD Imaging Acquisition Workgroup
Mar 27, 2018·Annual Review of Clinical Psychology·Ryan BogdanArpana Agrawal
Oct 20, 2018·The American Journal of Psychiatry·Scott MackeyUNKNOWN ENIGMA Addiction Working Group
Mar 16, 2019·Drug and Alcohol Dependence·William H HamptonIngrid R Olson
Apr 18, 2019·Nature Communications·Tian GeJordan W Smoller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.