Polyglycolic acid microneedles modified with inkjet-deposited antifungal coatings

Biointerphases
Ryan D BoehmRoger J Narayan

Abstract

In this study, the authors examined use of piezoelectric inkjet printing to apply an antifungal agent, voriconazole, to the surfaces of biodegradable polyglycolic acid microneedles. Polyglycolic acid microneedles with sharp tips (average tip radius = 25 ± 3 μm) were prepared using a combination of injection molding and drawing lithography. The elastic modulus (9.9 ± 0.3 GPa) and hardness (588.2 ± 33.8 MPa) values of the polyglycolic acid material were determined using nanoindentation and were found to be suitable for use in transdermal drug delivery devices. Voriconazole was deposited onto the polyglycolic acid microneedles by means of piezoelectric inkjet printing. It should be noted that voriconazole has poor solubility in water; however, it is readily soluble in many organic solvents. Optical imaging, scanning electron microscopy, energy dispersive x-ray spectrometry, and Fourier transform infrared spectroscopy were utilized to examine the microneedle geometries and inkjet-deposited surface coatings. Furthermore, an in vitro agar plating study was performed on the unmodified, vehicle-modified, and voriconazole-modified microneedles. Unlike the unmodified and vehicle-modified microneedles, the voriconazole-modified microneedl...Continue Reading

References

Jun 10, 1998·Journal of Biomedical Materials Research·M Epple, O Herzberg
Feb 18, 2004·Annals of Biomedical Engineering·Catherine G Ambrose, Thomas Oscar Clanton
Mar 26, 2004·Nature Reviews. Drug Discovery·Mark R PrausnitzRobert Langer
May 20, 2004·The British Journal of Dermatology·F ChabriJ Birchall
Jun 24, 2004·Pharmaceutical Research·Wijaya MartantoMark R Prausnitz
Sep 1, 2004·International Journal of Pharmaceutics·Julia BrauneckerRuth E Cameron
May 4, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jung-Hwan ParkMark R Prausnitz
Mar 28, 2006·Advanced Drug Delivery Reviews·Erin L Giudice, James D Campbell
Jun 29, 2007·Pharmaceutical Research·Chandra Sekhar Kolli, Ajay K Banga
Jul 30, 2008·Biomedical Microdevices·M I HaqJ C Birchall
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·Anurag PandeyPranesh B Aswath
Mar 9, 2010·Expert Opinion on Drug Delivery·Shaun D GittardRoger J Narayan
Mar 2, 2011·Journal of Pharmaceutical Sciences·Niklas SandlerJouko Peltonen
Aug 11, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nikolaos ScoutarisClive J Roberts
Aug 30, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nidambur Vasudev BallalKadengodlu Seetharama Bhat
Nov 30, 2011·AIP Advances·R D BoehmR J Narayan
Jan 31, 2012·Biofabrication·Ryan D BoehmRoger J Narayan
May 12, 2012·Advanced Drug Delivery Reviews·Yeu-Chun KimMark R Prausnitz
May 29, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Biswadip SinhaGurudutta Pattnaik
Jul 27, 2012·Biomedical Microdevices·Cheng Guo LiHyungil Jung

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Citations

Nov 12, 2015·Pharmaceutics·Rita Haj-AhmadZeeshan Ahmad
Jan 2, 2016·International Journal of Pharmaceutics·Evin A AllenAbina M Crean
Nov 13, 2015·Expert Opinion on Drug Delivery·N Sanoj RejinoldYeu-Chun Kim
Feb 13, 2016·Biointerphases·Ryan D BoehmRoger J Narayan
May 20, 2016·Pharmaceutical Research·Mohamed A AlhnanBasel Arafat
Jul 1, 2020·Advanced Materials·Rezvan JamaledinPooyan Makvandi
Jul 25, 2019·Current Pharmaceutical Design·Anish ChandekarGaurav Gupta
Dec 7, 2018·Current Pharmaceutical Design·Musarrat H WarsiSaba Khan
Aug 7, 2019·Pharmaceutics·Andrew Kjar, Yu Huang
Jan 19, 2021·AAPS PharmSciTech·Vanessa Marcia Vaz, Lalit Kumar
Sep 10, 2020·Heliyon·Abhinava GargGoutam Rath
Feb 5, 2021·International Journal of Pharmaceutics·Nafiseh ElahpourFilippo Berto
Jun 5, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nataša Bubić PajićSnežana Savić

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