Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Zi-ting ZhangJin-ku Bao

Abstract

Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins, has been well-known to possess several biological functions including apoptosis-inducing activities. However, the precise mechanisms of GNA-related lectins to induce apoptosis remains to be clarified. In this study, we showed that Polygonatum cyrtonema lectin (PCL) and Ophiopogon japonicus lectin (OJL), the two mannose-binding GNA-related lectins, could induce murine fibrosarcoma L929 cell apoptosis. In addition, we found that there was a close link between their sugar-binding and apoptosis-inducing activities. Interestingly, we further confirmed that the mechanism of lectin-induced apoptosis was a caspase-dependent pathway. Moreover, we found that the two lectins could amplify tumor necrosis factor α (TNFα)-induced apoptosis. Taken together, these findings would open a new perspective for GNA-related lectins as potential anti-tumor agents.

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Citations

Jan 23, 2014·Applied Biochemistry and Biotechnology·Syed Rashel Kabir, Md Abu Reza
Jan 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Syed Rashel KabirM Tofazzal Hossain
Jul 30, 2011·The International Journal of Biochemistry & Cell Biology·Lei-lei FuJin-ku Bao
Feb 19, 2011·Biochemical and Biophysical Research Communications·Shu-ya WangBo Liu
Nov 14, 2015·Critical Reviews in Food Science and Nutrition·Blanca Hernández-Ledesma, Chia-Chien Hsieh
Jul 4, 2017·International Journal of Molecular Sciences·Laura Elena Estrada-MartínezTeresa García-Gasca
Aug 28, 2020·Acta Biochimica Et Biophysica Sinica·Na JiangChuanfang Wu
Aug 11, 2019·International Journal of Biological Macromolecules·Priscila Marcelino Dos Santos SilvaLuana Cassandra Breitenbach Barroso Coelho

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