Polygonatum rhizoma affects antioxidant defense systems without changing mRNA expression in diet-induced hypercholesterolemic rabbits

Journal of Medicinal Food
Seon-Min JeonMyung-Sook Choi

Abstract

This study was conducted to determine the antioxidant effects of a Polygonatum extract compared with the major antioxidant, vitamin E, in rabbits fed a high-cholesterol diet. Rabbits were given a high-cholesterol (0.5%, wt/wt) diet with vitamin E (0.03%, wt/wt) or a Polygonatum extract (0.05%, wt/wt) for 8 weeks. The body weight gain (g/week) was only significantly increased only in the high-cholesterol-fed control group, yet the relative liver weight was significantly lower in the Polygonatum group compared with the other groups. The supplementation of vitamin E and Polygonatum extract led to an increase in the hepatic catalase (CAT) activity without any change in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Hepatic total glutathione content was significantly higher in the Polygonatum group than in the other groups. The level of hepatic mitochondrial H(2)O(2) was significantly lower in the two supplemented groups compared with the control group, whereas the level of cytosolic H(2)O(2) was only significantly lower in the Polygonatum group than in the control group. The level of plasma thiobarbituric acid-reactive substances (TBARS) was only significantly lower in the vitamin E group, whereas the le...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Mar 1, 1992·The Journal of Nutrition·E D Harris
Jul 29, 1991·FEBS Letters·M I MacknessP N Durrington
Jan 1, 1991·The American Journal of Clinical Nutrition·H EsterbauerG Waeg
Nov 15, 1986·Archives of Biochemistry and Biophysics·H Sies, R Mehlhorn
Feb 15, 1983·Archives of Biochemistry and Biophysics·G W BurtonK U Ingold
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Harman
May 20, 1993·The New England Journal of Medicine·M J StampferW C Willett
Nov 1, 1995·Biological & Pharmaceutical Bulletin·T Miura, A Kato
Sep 18, 1998·Current Opinion in Lipidology·M I MacknessG C Fonarow
May 25, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M UpstonR Stocker
Feb 19, 2000·Life Sciences·T B NgZ T Wang
Mar 1, 2000·Biochemical and Biophysical Research Communications·M MacknessA Bouiller
Aug 19, 2003·European Journal of Nutrition·Francesco VisioliMarisa Porrini
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Feb 26, 2004·Journal of the American Chemical Society·Veronica De SilvaSheldon W May
Apr 14, 2004·Current Medicinal Chemistry·Shosuke Kojo
Apr 24, 2004·Free Radical Research·Henrik TraulsenHelmut Sies

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Citations

Feb 22, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Vicência Mara Rodrigues de LimaFlair José Carrilho
Jun 22, 2016·Journal of Natural Medicines·Ji Eun LeeWoong Mo Yang
Jul 2, 2005·Current Opinion in Lipidology·Michael Aviram, Mira Rosenblat
Aug 6, 2015·Canadian Journal of Physiology and Pharmacology·Yilmaz CigremisGultekin Atalan

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