Polyhedral organelles compartmenting bacterial metabolic processes

Applied Microbiology and Biotechnology
Thomas A Bobik

Abstract

Bacterial polyhedral organelles are extremely large macromolecular complexes consisting of metabolic enzymes encased within a multiprotein shell that is somewhat reminiscent of a viral capsid. Recent investigations suggest that polyhedral organelles are widely used by bacteria for optimizing metabolic processes. The distribution and diversity of these unique structures has been underestimated because many are not formed during growth on standard laboratory media and because electron microscopy is required for their observation. However, recent physiological studies and genomic analyses tentatively indicate seven functionally distinct organelles distributed among over 40 genera of bacteria. Functional studies conducted thus far are consistent with the idea that polyhedral organelles act as microcompartments that enhance metabolic processes by selectively concentrating specific metabolites. Relatively little is known about how this is achieved at the molecular level. Possible mechanisms include regulation of enzyme activity or efficiency, substrate channeling, a selectively permeable protein shell, and/or differential solubility of metabolites within the organelle. Given their complexity and distinctive structure, it would not be...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H FukuzawaS Miyachi
May 1, 1990·Journal of General Microbiology·R M Jeter
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J PierceJ G Williams
Sep 1, 1988·Journal of Bacteriology·D M Roof, J R Roth
Feb 1, 1970·Journal of Bacteriology·J M ShivelyJ W Greenawalt
Mar 1, 1969·Journal of Bacteriology·E Gantt, S F Conti
Sep 1, 1994·Journal of Bacteriology·P ChenJ R Roth
Jan 19, 1999·Annual Review of Microbiology·J M ShivelyW G Meijer
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·A KaplanL Reinhold
Nov 28, 2001·Applied and Environmental Microbiology·G C CannonJ M Shively
Jan 30, 2003·Journal of Experimental Botany·Murray R Badger, G Dean Price
Mar 12, 2004·Annual Review of Plant Physiology and Plant Molecular Biology·Aaron Kaplan, Leonora Reinhold
Mar 24, 2005·Bioscience, Biotechnology, and Biochemistry·Takamasa TobimatsuTetsuo Toraya
Apr 9, 2005·Microbiology·Edith M SampsonThomas A Bobik
Aug 6, 2005·Science·Cheryl A KerfeldTodd O Yeates
Sep 1, 1995·Applied and Environmental Microbiology·R S EnglishJ M Shively
Oct 1, 1986·Plant Physiology·Y MarcusA Kaplan

❮ Previous
Next ❯

Citations

Aug 6, 2008·Nature Reviews. Microbiology·Todd O YeatesJessup M Shively
Sep 5, 2008·Nature Structural & Molecular Biology·Sabine Heinhorst, Gordon C Cannon
Jan 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tajul IslamNils-Kåre Birkeland
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chenguang FanThomas A Bobik
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Chenguang FanThomas A Bobik
Oct 25, 2011·Nucleic Acids Research·Robert J ConradoMatthew P DeLisa
Dec 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simon Conway Morris
Jan 11, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John A RavenStephen C Maberly
Feb 6, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Kiel NikolakakisMartin Sagermann
Feb 23, 2008·Science·Shiho TanakaTodd O Yeates
Oct 9, 2007·Applied and Environmental Microbiology·Lawrence P WackettStephan M Cameron
May 21, 2013·Journal of Bacteriology·Maria R Gomez-GarciaDevaki Bhaya
Sep 28, 2010·Journal of Bacteriology·Balaraj B MenonGordon C Cannon
Oct 3, 2006·Journal of Bacteriology·Sabine HeinhorstGordon C Cannon
Mar 22, 2008·Annual Review of Biochemistry·Dylan M Morris, Grant J Jensen
Mar 3, 2010·Annual Review of Biophysics·Todd O YeatesShiho Tanaka
Nov 13, 2008·Annual Review of Physical Chemistry·L LizanaO Orwar
May 7, 2009·Theoretical Biology & Medical Modelling·Alexei Kurakin
Apr 5, 2013·PloS One·Ildefonso M De la FuenteJuan Veguillas
Oct 20, 2010·International Journal of Molecular Sciences·Ildefonso Martínez de la Fuente
Apr 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sabine Heinhorst, Gordon C Cannon
Sep 18, 2014·FEMS Microbiology Reviews·Víctor de LorenzoAntoine Danchin
Mar 31, 2011·Theoretical Biology & Medical Modelling·Alexei Kurakin
May 19, 2012·Nature Chemical Biology·Elizabeth A FelnagleJames C Liao
Oct 10, 2013·Critical Reviews in Biotechnology·Neus Ferrer-MirallesAntonio Villaverde
Feb 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Chiranjit ChowdhuryThomas A Bobik
Apr 24, 2012·Trends in Genetics : TIG·Keren Nevo-DinurOrna Amster-Choder
Feb 15, 2011·Current Opinion in Structural Biology·Todd O YeatesThomas A Bobik
Aug 3, 2007·Journal of Molecular Biology·Cristina V IancuGrant J Jensen
Jan 30, 2009·Protein Science : a Publication of the Protein Society·Morgan BeebyTodd O Yeates
Oct 22, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shouqiang ChengThomas A Bobik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Shouqiang ChengThomas A Bobik
Annual Review of Microbiology
Cheryl A KerfeldGordon C Cannon
© 2021 Meta ULC. All rights reserved