Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease

Journal of Neuroscience Research
Xiaoqing CaiJiankang Liu

Abstract

To find effective agents for Parkinson's disease (PD) prevention and therapy, we examined the protective effects of the polyhydroxylated fullerene derivative C(60)(OH)(24) in a 1-methyl-4-phenylpyridinium (MPP(+)) -induced acute cellular PD model in human neuroblastoma cells and the free radical scavenging effects in this model with an electron spin resonance (ESR) spectrometer. Pretreatment with C(60)(OH)(24) at concentrations greater than 20 microM showed significant protective effects on MPP(+) -induced loss in cell viability, decreases in mitochondrial function (including mitochondrial membrane potential and activities of complex I and II), and increases in the levels of reactive oxygen species and oxidative damage to DNA and proteins. In addition, C(60)(OH)(24) acts as a phase 2 enzyme inducer to protect cells from MPP(+) -induced decreases in expression of nuclear factor-E2-related factor 2, expression and activity of gamma-glutamyl cysteine ligase and level of glutathione. The ESR study showed that C(60)(OH)(24) is a powerful radical scavenger for superoxide, hydroxyl, and lipid radicals. These data suggest that C(60)(OH)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect a...Continue Reading

References

May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S T SmileyL B Chen
Nov 17, 1994·Annals of the New York Academy of Sciences·R M WuC C Chiueh
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·L L DuganT S Lin
Apr 16, 1998·Mechanisms of Ageing and Development·M V AksenovaD A Butterfield
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Sep 29, 1999·The American Journal of Clinical Nutrition·J W AndersonD T Remley
Mar 29, 2000·Environmental and Molecular Mutagenesis·R R TiceY F Sasaki
Jun 8, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S BuckR Arking
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S M CardosoC R Oliveira
Apr 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ranjita BetarbetJ Timothy Greenamyre
Jun 11, 2002·Biochemical and Biophysical Research Communications·Sarah FoleyChristian Larroque
Apr 1, 2003·Annals of Neurology·M Flint Beal
Jun 20, 2003·Analytical Biochemistry·Collin C WhiteTerrance J Kavanagh
Dec 4, 2003·European Journal of Medicinal Chemistry·Susanna BosiMaurizio Prato
Jan 22, 2004·JAMA : the Journal of the American Medical Association·Anthony H V Schapira, C Warren Olanow
May 12, 2004·Current Medicinal Chemistry·A R SmithT M Hagen
Oct 20, 2004·Nitric Oxide : Biology and Chemistry·Snezana M MirkovRadmila Z Kovacevic
Jan 19, 2005·Molecular Neurobiology·Rosa A González-PoloJosé M Fuentes
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Celine PerierMiquel Vila
Feb 16, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aleksandra IsakovicVladimir Trajkovic
Mar 31, 2007·Journal of the American Chemical Society·Michael D DienerSaed Mirzadeh

❮ Previous
Next ❯

Citations

Nov 12, 2013·Advances in Colloid and Interface Science·Kannan Badri Narayanan, Hyun Ho Park
Jun 26, 2010·Journal of Biochemistry·Masanori HorieHitoshi Iwahashi
Jan 1, 2014·International Journal of Nanomedicine·Xinlin YangQuanjun Cui
Jul 4, 2009·Nanomedicine·Ari NowacekHoward E Gendelman
May 31, 2014·International Journal of Nanomedicine·Xinlin YangXudong Li
Apr 2, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Alessandra Martins da RochaJosé Maria Monserrat
Nov 14, 2013·BioMed Research International·Jacek GrebowskiAnita Krokosz
Jun 13, 2015·Oxidative Medicine and Cellular Longevity·Carlos Fernández-MorianoM Pilar Gómez-Serranillos
Apr 26, 2011·Ecotoxicology and Environmental Safety·Boris JovanovićDušan Palić
Dec 3, 2016·Physical Chemistry Chemical Physics : PCCP·Milan VranešAleksandar Djordjevic
Jun 1, 2017·Environmental Science and Pollution Research International·Tihomir KovačIvica Strelec
Nov 30, 2011·Nanomedicine·Sulbha K SharmaMichael R Hamblin
Aug 9, 2018·Nanomedicine·Weiyuan ZhangZhiyong He
Jul 20, 2014·Applied and Environmental Microbiology·Arunava PradhanFernanda Cássio
Mar 17, 2010·Nature Nanotechnology·Vijay KrishnaBrij Moudgil
Sep 8, 2010·Small·Vijay KrishnaBrij Moudgil
Sep 30, 2010·Journal of Applied Toxicology : JAT·Tian ChenShun-Qing Xu
Dec 7, 2013·Nanoscale·Zaixing YangRuhong Zhou
Oct 3, 2009·The Journal of Toxicological Sciences·Hisae AoshimaNobuhiko Miwa
Sep 29, 2020·F1000Research·Senthil Velan BhoopalanMitchell J Weiss
May 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abuzer Alp YetisginOzlem Kutlu
May 25, 2010·Toxicology Mechanisms and Methods·Branislava SrdjenovicVelibor Vasovic
Aug 25, 2011·Chemical Communications : Chem Comm·Davide GiustDavide Bonifazi
Jun 2, 2009·Journal of Applied Toxicology : JAT·Jing-Ying XuQing-Nuan Li
Jan 10, 2011·Science and Technology of Advanced Materials·Yukio Nagasaki

❮ Previous
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