Polyinosinic-polycytidylic acid induces the expression of GRO-alpha in BEAS-2B cells

Inflammation
Koji YamashitaKei Satoh

Abstract

Growth-related oncogene protein-alpha (GRO-alpha)/CXCLl is a chemokine that activates neutrophils and plays an important role in inflammatory reactions. Polyinosinic-polycytidylic acid (poly IC) is a synthetic double-stranded RNA (dsRNA), which is a ligand for Toll-like receptor-3. Poly IC mimics viral infection when applied to cells and induces inflammatory and immune responses. In the present study, we found the induction of GRO-alpha in BEAS-2B bronchial epithelial cells treated with poly IC. Pretreatment of cells with 2-aminopurine, an inhibitor for dsRNA-dependent protein kinase (PKR), inhibited the expression of GRO-alpha-induced by poly IC. Overexpression of interferon-regulatory factor-3 (IRF-3) or retinoic-acid inducible gene-I (RIG-I) enhanced the induction of GRO-alpha by poly IC. PKR, IRF-3, and RIG-I may be involved in the poly IC-induced expression of GRO-alpha in BEAS-2B cells. Airway viral infection may elicit GRO-alpha expression in the bronchial epithelium, which may be implicated in inflammatory and immune reactions.

References

May 1, 1990·The Journal of Experimental Medicine·B MoserM Baggiolini
Dec 1, 1986·Journal of Cellular Physiology·A Richmond, H G Thomas
Nov 11, 1999·Oncogene·B R Williams
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mitsutoshi YoneyamaTakashi Fujita
Mar 14, 2002·Biochemical and Biophysical Research Communications·Tadaatsu ImaizumiKei Satoh
Sep 6, 2002·The European Respiratory Journal·K WolfM Pfeifer
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·James E GernWilliam W Busse
May 18, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K IekiM Adachi
Jun 12, 2004·American Journal of Respiratory Cell and Molecular Biology·Quan ShaRobert P Schleimer
Sep 17, 2004·Endothelium : Journal of Endothelial Cell Research·T ImaizumiK Wakabayashi

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Citations

Jun 11, 2009·The Journal of Membrane Biology·Tamene MelkamuScott M O'Grady
Jan 5, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Curtis KuoBrian G Oliver
Dec 20, 2007·The Journal of General Virology·Richard E Randall, Stephen Goodbourn
May 9, 2007·Journal of Atherosclerosis and Thrombosis·Tadaatsu ImaizumiKei Satoh
Oct 20, 2006·Virology·Kay ChildsStephen Goodbourn
Jun 21, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Yuta KoizumiKen Ohta
Mar 9, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Karina V BarrosVera L Flor Silveira
May 5, 2020·Experimental Lung Research·Toshihiro ShiratoriSadatomo Tasaka

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