Polyketides From the Endophytic Fungus Cladosporium sp. Isolated From the Mangrove Plant Excoecaria agallocha

Frontiers in Chemistry
Liping WangWeiming Zhu

Abstract

Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.

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Citations

Feb 7, 2020·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jan 22, 2019·Natural Product Research·Muhammad AminShu-Hua Qi
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
Jul 3, 2021·Journal of Fungi·Rafael Dorighello CadamuroGislaine Fongaro
Oct 9, 2021·Natural Product Research·Amal SallamMarwa Elsbaey
Oct 9, 2021·Natural Product Reports·Senhua ChenZhigang She

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Methods Mentioned

BETA
column chromatography
NMR
single crystal diffraction
X-ray
glycosidation

Software Mentioned

Gaussian
SHELXL
SHELXS
HyperChem

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