PMID: 26328449Sep 4, 2015Paper

Poly(L-lactide) Nanoparticles Reduce Amphotericin B Cytotoxicity and Maintain Its In Vitro Antifungal Activity

Journal of Nanoscience and Nanotechnology
Diani Meza CasaRubiana Mara Mainardes

Abstract

In this study, poly(L-lactide) (PLA) nanoparticles containing amphotericin B (AmB) were developed, and the in vitro cytotoxicity to human erythrocytes and efficacy on strains of Candida spp. were evaluated. The nanoparticles were prepared using an emulsion/solvent evaporation method and were characterized with respect to size, size distribution, AmB encapsulation efficiency, AmB state of aggregation, and AmB in vitro release profile. The mean particle size was 225 nm, and the AmB encapsulation efficiency was over 69%. The AmB in vitro release profile revealed a burst effect within the first 24 h, which released approximately 10% of AmB, followed by a sustained release of approximately 30% of AmB over 30 days. The AmB nanoparticles presented a very low index of hemolysis compared to free AmB, which lysed more than 80% of erythrocytes in the first 2 h of incubation. The AmB-loaded PLA nanoparticles were as effective as free AmB against strains of Candida spp., considering their sustained release profile. Thus, PLA nanoparticles can deliver AmB with reduced toxicity while maintaining its antifungal activity.

Citations

Nov 12, 2014·Pharmaceutical Development and Technology·Talita Cristina Moreira Moraes CarraroRubiana Mara Mainardes
Oct 1, 2016·Acta Biomaterialia·Ying WangPui Lai Rachel Ee
Sep 28, 2017·Human Vaccines & Immunotherapeutics·Chao LiuGang Liu
Mar 3, 2018·Mycopathologia·Daniel Brustolin LudwigRubiana Mara Mainardes
Aug 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·M BekhoucheJ-C Farges
Dec 11, 2019·Cancers·Francisco Fabian Razura-CarmonaJorge Alberto Sánchez-Burgos
Oct 18, 2019·Future Medicinal Chemistry·Hongmei XuZhimei Song
Oct 6, 2020·Macromolecular Bioscience·Anna E CaprificoGianpiero Calabrese
Jan 16, 2021·International Journal of Biological Macromolecules·Emilli AntonioRubiana Mara Mainardes
Feb 25, 2019·International Journal of Biological Macromolecules·Fernanda Matoso SombraRegina Célia Monteiro de Paula
Nov 18, 2019·International Journal of Biological Macromolecules·Fernanda M SombraRegina C M de Paula
Oct 6, 2018·Carbohydrate Polymers·Rossana Gabriela Del Jesus Vásquez MarcanoRubiana Mara Mainardes
Jun 23, 2020·International Journal of Biological Macromolecules·Thaysa Ksiaskiewcz KaramCelso Vataru Nakamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Colloids and Surfaces. B, Biointerfaces
Luiz Henrique GuerreiroLuís Maurício T R Lima
International Journal of Clinical and Experimental Medicine
Xiaolong TangYong Liang
Revista Da Sociedade Brasileira De Medicina Tropical
Cecília Rocha da SilvaHélio Vitoriano Nobre Júnior
© 2021 Meta ULC. All rights reserved