Polylactic acid nano- and microchamber arrays for encapsulation of small hydrophilic molecules featuring drug release via high intensity focused ultrasound

Nanoscale
Meiyu GaiGleb B Sukhorukov

Abstract

Long term encapsulation combined with spatiotemporal release for a precisely defined quantity of small hydrophilic molecules on demand remains a challenge in various fields ranging from medical drug delivery, controlled release of catalysts to industrial anti-corrosion systems. Free-standing individually sealed polylactic acid (PLA) nano- and microchamber arrays were produced by one-step dip-coating a PDMS stamp into PLA solution for 5 s followed by drying under ambient conditions. The wall thickness of these hydrophobic nano-microchambers is tunable from 150 nm to 7 μm by varying the PLA solution concentration. Furthermore, small hydrophilic molecules were successfully in situ precipitated within individual microchambers in the course of solvent evaporation after sonicating the PLA@PDMS stamp to remove air-bubbles and to load the active substance containing solvent. The cargo capacity of single chambers was determined to be in the range of several picograms, while it amounts to several micrograms per cm2. Two different methods for sealing chambers were compared: microcontact printing versus dip-coating whereby microcontact printing onto a flat PLA sheet allows for entrapment of micro-air-bubbles enabling microchambers with bot...Continue Reading

References

Dec 4, 2003·Analytical Chemistry·Jessamine Ng LeeGeorge M Whitesides
Apr 7, 2005·Journal of the American Chemical Society·Zuzanna SiwyCharles R Martin
Mar 21, 2009·Bioorganic & Medicinal Chemistry·Amir H Faraji, Peter Wipf
Jan 23, 2010·Nature Materials·Martien A Cohen StuartSergiy Minko
Sep 8, 2010·Advanced Materials·Brian P TimkoDaniel S Kohane
Mar 24, 2011·Nature Communications·James A Callow, Maureen E Callow
Aug 16, 2011·Physical Review Letters·P V RuijgrokM Orrit
Mar 14, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Maxim V KiryukhinGleb B Sukhorukov
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Nov 7, 2012·Macromolecular Rapid Communications·Maxim V KiryukhinGleb B Sukhorukov
Sep 4, 2013·Advanced Materials·Ekaterina V Skorb, Helmuth Möhwald
Oct 3, 2013·ACS Nano·Qiangying Yi, Gleb B Sukhorukov
Jan 8, 2014·Nano Letters·Haiyan MaLene B Oddershede
Apr 18, 2014·Journal of Nanoscience and Nanotechnology·Johannes FruehQiang He
May 12, 2015·Advanced Healthcare Materials·Minjun XuanJunbai Li
Jun 18, 2015·Nano Letters·Liselotte JauffredLene B Oddershede
Oct 1, 2015·Advanced Materials·Xiankun LinQiang He
Aug 21, 2016·Journal of Biomedical Materials Research. Part a·Maria S SavelyevaBogdan V Parakhonskiy
Sep 1, 2010·Comprehensive Reviews in Food Science and Food Safety·Majid JamshidianStéphane Desobry

❮ Previous
Next ❯

Citations

Jan 5, 2019·Recent Patents on Nanotechnology·Reena SiwachHarish Dureja
Aug 7, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alexey V ErmakovGleb B Sukhorukov
Aug 3, 2019·Journal of Functional Biomaterials·Carlos M WellsJ Amber Jennings
Dec 17, 2019·Recent Patents on Nanotechnology·N V SvarovskayaM I Lerner
Dec 5, 2019·Recent Patents on Nanotechnology·Gobad Behzadi PourMasoud Mirzaee
Jun 25, 2021·Nanoscale·Hongda ZhouDmitry Shchukin
Feb 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·E Shchukina, D G Shchukin
Oct 10, 2018·ACS Applied Materials & Interfaces·Olga A SindeevaGleb B Sukhorukov
Dec 16, 2020·ACS Biomaterials Science & Engineering·Maxim V KiryukhinZee Upton
Jan 7, 2021·ACS Applied Materials & Interfaces·Valeriya KudryavtsevaGleb B Sukhorukov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.