Poly(lactic-co-glycolic acid) enhances maturation of human monocyte-derived dendritic cells

Journal of Biomedical Materials Research. Part a
Mutsumi Yoshida, Julia E Babensee

Abstract

Immature dendritic cells (iDCs) were derived from human peripheral blood monocytes, and treated with 75:25 poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) or film to assess the resultant dendritic cell (DC) maturation as compared to positive control of lipopolysaccharide (LPS) treatment for DC maturation or negative control of untreated iDCs. The effect of PLGA contact on DC maturation was examined as one possible explanation for the PLGA adjuvant effect we have observed in the enhancement of an immune response to codelivered model antigen, as adjuvants act through the maturation of DCs. Culturing iDCs with PLGA MPs or PLGA film resulted in morphology similar to that of LPS-matured DCs and the association, or possible internalization, of PLGA MPs. Furthermore, biomaterial-treated iDCs demonstrated an increase in MHC class II and costimulatory molecule expression compared to iDCs but to a lower level than that of LPS-matured DCs. Direct iDC contact with PLGA MPs was necessary for maturation. Immature DCs exposed to PLGA MPs were stimulatory of allogeneic T-cell proliferation, whereas cells exposed to PLGA film were not. Further, PLGA MPs supported a moderate delayed type hypersensitivity reaction in mice indicative of ...Continue Reading

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Citations

Mar 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kyle E BroadersJean M J Fréchet
Feb 15, 2013·Tissue Engineering. Part a·Alexandra BayrakMartina Seifert
Oct 10, 2006·Journal of Biomaterials Science. Polymer Edition·Mutsumi Yoshida, Julia E Babensee
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Oct 28, 2010·Acta Biomaterialia·Peng Meng KouJulia E Babensee
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Mar 11, 2009·Journal of Biomedical Materials Research. Part a·Sucharita P Shankar, Julia E Babensee
Apr 9, 2009·Journal of Biomedical Materials Research. Part a·Sucharita P ShankarJulia E Babensee
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