Polylactide stereocomplex-based electrospun materials possessing surface with antibacterial and hemostatic properties

Biomacromolecules
Mariya SpasovaDobri Danchev

Abstract

Novel fibrous materials of stereocomplex between high-molecular-weight poly(d- or l-)lactide (HMPDLA or HMPLLA) and diblock copolymers consisting of poly(l- or d-)lactide and poly(N,N-dimethylamino-2-ethyl methacrylate) blocks, respectively (PLLA-block-PDMAEMA or PDLA-block-PDMAEMA), were prepared by solution electrospinning. Fibers with mean diameters ranging from 1400 to 1700 nm were obtained. The stereocomplex formation was evidenced by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analyses. Annealing at 100 degrees C for 8 h resulted in the appearance of crystalline peaks at 2theta values of 12, 21, and 24 degrees for PLA stereocomplex. X-ray photoelectron spectroscopy (XPS) analyses revealed the gradient composition of the fibers with a surface enriched in tertiary amino groups from PDMAEMA blocks. The availability of tertiary amino groups imparts hemostatic and antibacterial properties to the stereocomplex fibrous materials, as indicated by the performed tests on blood cells and on pathogenic microorganisms.

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Citations

Apr 19, 2013·Journal of Biomaterials Science. Polymer Edition·Huan Zhou, Sarit B Bhaduri
Jun 9, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Nikoleta StoyanovaIliya Rashkov
Jan 20, 2016·Advanced Drug Delivery Reviews·Hideto Tsuji
Dec 27, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Daniela VirovskaDaniela Karashanova
Nov 26, 2015·The Journal of Physical Chemistry. B·Ruihua LvQingxian Liu
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Sep 30, 2014·Macromolecular Rapid Communications·Veluska AriasAnn-Christine Albertsson
Apr 30, 2016·Advanced Drug Delivery Reviews·Hideto Tsuji
Aug 14, 2012·Chemical Society Reviews·Sangram Keshari SamalPeter Dubruel
Nov 8, 2019·Advanced Healthcare Materials·Xiao-Xiong WangYun-Ze Long
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seung Hyuk ImSoo Hyun Kim

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