Polylaminin, a polymeric form of laminin, promotes regeneration after spinal cord injury

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Karla MenezesTatiana Coelho-Sampaio

Abstract

Regeneration of spinal cord injury (SCI) is a major topic of biomedical research. Laminin is an extracellular matrix protein implicated in neural development and regeneration, but despite that, there are no reports of exogenous laminin contributing to improve the outcome of experimental SCI. Here we investigated whether a biomimetic polymer of laminin assembled on pH acidification, henceforth called polylaminin, could be used to treat SCI in rats. Acute local injection of polylaminin, but not of nonpolymerized laminin, improved motor function after thoracic compression, partial or complete transection. In the latter case, the BBB score for open field locomotion 8 wk after lesion increased from 4.2 ± 0.48 to 8.8 ± 1.14 in animals treated with polylaminin of human origin. Accordingly, neurons retrogradely labeled from the sublesion stump were detected in the spinal cord and brain stem, indicating regrowth of short and long fibers across a complete transection. Polylaminin also played an unsuspected anti-inflammatory role, which underlies the early onset of its positive effects on locomotion from the first week after treatment. The beneficial effects of polylaminin were not observed in animals treated with the nonpolymerized prote...Continue Reading

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Citations

Jul 19, 2013·Neuroscience Bulletin·Agnes E Haggerty, Martin Oudega
Feb 4, 2014·Biomaterials·Alan P WeightmanDivya M Chari
Nov 7, 2013·BioMed Research International·Stefan Plantman
Nov 23, 2013·Journal of Neuroscience Research·Camila Hochman-MendezTatiana Coelho-Sampaio
Oct 9, 2014·PloS One·Camila Hochman-MendezTatiana Coelho-Sampaio
Oct 6, 2016·Neuroscience Letters·Agnes E HaggertyMartin Oudega
Mar 23, 2017·Journal of Biomedical Materials Research. Part a·Katarzyna NawrotekPatrick Decherchi
Jan 24, 2018·Biomedical Materials·Agnes E HaggertyMartin Oudega
Oct 14, 2011·Macromolecular Bioscience·Elisabete FreireTatiana Coelho-Sampaio
Apr 11, 2018·Journal of Biomedical Materials Research. Part a·Agnes E HaggertyMartin Oudega
Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Camila Leal-LopesMari Cleide Sogayar
Apr 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ningning ChenFuxin Wei
Aug 23, 2020·International Journal of Molecular Sciences·Camila Hochman-MendezDoris A Taylor
Jul 18, 2017·Journal of Acupuncture and Meridian Studies·Raquel Nascimento de SouzaMagda Alves de Medeiros
Jan 20, 2019·Acta Biomaterialia·Agnes E HaggertyMartin Oudega

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