PMID: 11332884May 3, 2001Paper

Polylysine-porphycene conjugates as efficient photosensitizers for the inactivation of microbial pathogens

Journal of Photochemistry and Photobiology. B, Biology
L PoloElena Reddi

Abstract

Porphycenes are electronic isomers of porphyrins which, when neutral, display no appreciable photosensitizing action towards Gram-negative bacteria. The covalent binding of oligomeric polylysine moieties, which are cationic at physiological pH values, endows porphycenes with a significant phototoxic activity against Gram-negative bacteria while retaining their photoefficiency against a variety of microbial pathogens, including Gram-positive bacteria, fungi and mycoplasmas. The effect of the polylysine moiety is dependent on both the polylysine concentration and the degree of oligomerization. A suitable interplay among the various parameters opens the possibility to obtain either a broad spectrum of antimicrobial activity or a selective action toward a specific pathogen while minimizing the damage to human fibroblasts.

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Citations

Oct 13, 2010·Journal of Medicinal Chemistry·Xavier RagàsSanti Nonell
May 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael R Hamblin, Tayyaba Hasan
Dec 17, 2009·Photochemistry and Photobiology·Rivka CahanYeshayahu Nitzan
Feb 2, 2011·Antimicrobial Agents and Chemotherapy·Tsuimin TsaiChin-Tin Chen
May 25, 2004·Antimicrobial Agents and Chemotherapy·Faten GadMichael R Hamblin
Mar 29, 2005·Antimicrobial Agents and Chemotherapy·T MaischC Abels
May 27, 2005·Antimicrobial Agents and Chemotherapy·Tatiana N Demidova, Michael R Hamblin
Jun 29, 2010·Lasers in Surgery and Medicine·Xavier RagàsMichael R Hamblin
Sep 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Laura J BroughtonLeigh A Madden
Feb 12, 2002·Photochemistry and Photobiology·Michael R HamblinTayyaba Hasan
May 23, 2002·Photochemistry and Photobiology·Elena ReddiUgo Mazzucato
Apr 30, 2004·Photochemistry and Photobiology·Saskia A G LambrechtsJohan W M Lagerberg
Jun 22, 2006·Lasers in Surgery and Medicine·Giulio JoriGabrio Roncucci
Apr 4, 2008·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Liliana CostaAdelaide Almeida
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Oct 3, 2019·Journal of Functional Biomaterials·Patrícia DiogoJoão Miguel Santos
Apr 2, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Francesca GiuntiniRoss W Boyle
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