Poly(MAA-co-AN) hydrogels with improved mechanical properties for theophylline controlled delivery

Acta Biomaterialia
Yanling LuoYashao Chen

Abstract

A hydrophobically improved copolymer hydrogel was constructed and developed based on methacrylic acid (MAA) and acrylonitrile (AN) monomers. The swelling investigations indicated that the hydrogels were highly sensitive to the pH and ionic strength of the surrounding environment. The swelling ratios of the gels in stimulated intestinal fluids (SIF, pH 7.4) were higher than those in stimulated gastric fluids (SGF, pH 1.4), and followed a non-Fickian and a Fickian diffusion mechanism, respectively. The results match well with scanning electron microscopy observations showing that mesh sizes in hydrogels in SGF are larger and more patulous than in SIF. It is believed that the phenomena are concerned with the electrostatic repulsion originating from the formation and dissociation of carboxyl groups, as well as a charge screening effect of the cations leading to the reduction of osmotic pressure. A dynamic mechanical analyzer revealed that the addition of hydrophobic AN units notably improved the compression mechanical properties of the control sample. With an increase in AN concentrations, the ability for the copolymers to resist compression deformation enhanced in distilled water and the compression strains have almost the same va...Continue Reading

Citations

Dec 15, 2010·Journal of Biomaterials Science. Polymer Edition·Hong-Wei DiYun-Fei Nan
Mar 14, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Mehlika PulatNilay Demirkol Karahan
Oct 8, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yan-Ling LuoChao Ma
Sep 21, 2010·Small·Songjun LiShunsheng Cao
Oct 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shengzhong ZhouJoachim H G Steinke

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