Polymannuronic acid ameliorated obesity and inflammation associated with a high-fat and high-sucrose diet by modulating the gut microbiome in a murine model

The British Journal of Nutrition
Fang LiuQing-Juan Tang

Abstract

Polymannuronic acid (PM), one of numerous alginates isolated from brown seaweeds, is known to possess antioxidant activities. In this study, we examined its potential role in reducing body weight gain and attenuating inflammation induced by a high-fat and high-sucrose diet (HFD) as well as its effect on modulating the gut microbiome in mice. A 30-d PM treatment significantly reduced the diet-induced body weight gain and blood TAG levels (P2·0). PM also had a profound impact on the microbial composition in the gut microbiome and resulted in a distinct microbiome structure. For example, PM significantly increased the abundance of a probiotic bacterium, Lactobacillus reuteri (log10 LDA score>2·0). Together, our results suggest that PM may exert its immunoregulatory effects by enhancing proliferation of several species with probiotic activities while repressing the abundance of the microbial taxa that harbor potential pathogens. Our findings should facilitate mechanistic studies on PM as a potential bioactive compound to alleviate obesity and the metabolic syndrome.

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Citations

Mar 12, 2020·Critical Reviews in Food Science and Nutrition·Tatiane Ferreira da SilvaAna Lúcia Barretto Penna
Feb 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aroa Lopez-SantamarinaAlberto Cepeda
May 5, 2018·Frontiers in Microbiology·Qinghui MuXin M Luo
Aug 6, 2019·Frontiers in Microbiology·Xiaowei MaWei Xue
Mar 4, 2020·Marine Drugs·Maochen XingShuliang Song
Oct 20, 2020·Frontiers in Nutrition·Martin GottelandSebastián Rosenfeld
Feb 23, 2021·International Journal of Biological Macromolecules·Chuhuan HuYapeng Fang
Mar 23, 2021·Communications Biology·Christian DienerSean M Gibbons
Dec 14, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Djésia ArnoneLaurent Peyrin-Biroulet

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