PMID: 16633180Apr 25, 2006Paper

Polymer-based biodegradable drug delivery systems in pain management

The Journal of Craniofacial Surgery
Mohamed Al MalyanNureddin Ashammakhi

Abstract

Pain is an unpleasant sensory experience commonly produced by damage to bodily tissues and it is one of the most significant public health problems, because 21.5% of the world population is estimated to suffer from pain. It results in a total loss of more than 165 billion US dollars each year in the United States alone. Pain reflects a mixture of various pathophysiologic, psychologic, and genetic contributions. When undertreated, pain usually results in serious immune and metabolic upset. Therefore, it requires wide understanding and intensive effort for a better management. Currently, pain control is limited by the modest efficiency of the used drugs, the serious side effects of these drugs, and the inefficacy of conventional drug administration. By the introduction of the technology of biodegradable controlled-release devices into clinical practice, pain control not only benefits from these novel methods for a better delivery of various drugs, but the side effects of the drugs are reduced because use of the devices improves patient compliance. Biodegradable controlled-release devices are polymer-based devices that are designed to deliver drugs locally in a predesigned manner. Recently, there was a high interest in developing ...Continue Reading

References

May 10, 1991·Brain Research·J D EnglandS R Levinson
Mar 11, 1991·Neuroscience Letters·G J BirrellB D Grubb
Dec 1, 1990·Journal of Neurophysiology·M Devor, P D Wall
Nov 1, 1985·Chemical & Pharmaceutical Bulletin·T KojimaY Yoshida
Jan 1, 1981·Prostaglandins and Medicine·P V Peplow, P R Hurst
Jul 1, 1984·Chemical & Pharmaceutical Bulletin·T KojimaY Yoshida
Oct 1, 1982·Chemical & Pharmaceutical Bulletin·N WakiyamaM Nakano
Nov 1, 1981·Chemical & Pharmaceutical Bulletin·N WakiyamaM Nakano
Dec 1, 1994·Trends in Neurosciences·S Bevan, P Geppetti
Aug 1, 1995·British Journal of Anaesthesia·A Dray
Jan 1, 1995·Journal of Pharmaceutical Sciences·P Le CorreR Le Verge
Jun 22, 1995·The New England Journal of Medicine·C Stein
Oct 1, 1994·The Journal of Bone and Joint Surgery. American Volume·K L GarvinS Radio
Jan 3, 1994·Neuroscience Letters·H Holthusen, J O Arndt
Apr 1, 1994·Mayo Clinic Proceedings·S A Cross
May 1, 1993·Journal of Biomedical Materials Research·S F BernatchezJ Heller
Oct 1, 1995·Chemical & Pharmaceutical Bulletin·K DanjoA Otsuka
May 1, 1996·The Journal of Pharmacy and Pharmacology·A ConfortiF M Veronese
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·G Chandrashekar, N Udupa
Dec 1, 1996·Journal of Biomedical Materials Research·P A LisoA M Villar
Jan 1, 1997·Biomaterials·N Ashammakhi, P Rokkanen
Jan 1, 1997·Acta Anaesthesiologica Scandinavica·R Twycross
Jan 1, 1997·Acta Anaesthesiologica Scandinavica. Supplementum·L Nuutinen
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Jun 5, 1998·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P TörmäläP Rokkanen
Jul 21, 1998·JAMA : the Journal of the American Medical Association·O GurejeR Gater

❮ Previous
Next ❯

Citations

Nov 4, 2010·Journal of Materials Science. Materials in Medicine·H GautierJ M Bouler
Jun 10, 2008·Pharmaceutical Research·Erin E FalcoJohn P Fisher
Jan 28, 2012·Journal of the American Chemical Society·Stefan T YoheMark W Grinstaff
Jul 10, 2019·Chemical Communications : Chem Comm·Dinesh ShettyAli Trabolsi
Jun 28, 2017·Annals of Biomedical Engineering·Corinne N RigginJoseph Bernstein
Nov 13, 2021·Therapeutic Delivery·Sakshi V KhairnarPurnima D Amin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.