Polymer-Based Drug Delivery Systems, Development and Pre-Clinical Status

Current Pharmaceutical Design
Laura Jaimes-AguirreAhmadi Amirhosein

Abstract

The nanomedicine is considered as the application of nanotechnology in the medical field where nanoparticles are sized in the nanoscale range. Drug delivery technologies are becoming increasingly important as a scientific area of investigation. Controlled-release systems and drug-targeting systems represents an alternative to traditional delivery nanoparticles, and the use of polymers is increasing nowadays. Although polymers could be classified as excipients, they are capable of modifying the biopharmaceutical and biokinetic behaviour of the transported active molecule increasing its efficacy and stability, and reduced cytotoxicity on healthy peripheral tissues. The goal of this work is to collect and analyse the most current polymeric nanoparticles development as controlledrelease and drug-targeting systems in cancer, infectious diseases and immunomodulation areas, as alternatives to conventional therapies. This review provides an update on the polymeric nanoparticles development analysing the trend of polymeric-based drug delivery systems, future opportunities and challenges of this fast-growing area. With the thorough comprehension of biological effects depending on structure, it is possible to design specific systems for s...Continue Reading

Citations

Sep 25, 2020·Expert Opinion on Drug Delivery·Joydeb Majumder, Tamara Minko
Mar 1, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Yi YangZhiyong Qian
Jan 19, 2021·Macromolecular Bioscience·Liliana Aranda-LaraEnrique Morales-Avila
Nov 11, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jana KubackovaOndrej Holas
Mar 21, 2020·Mutation Research. Reviews in Mutation Research·Hadi SamadianAmirhossein Ahmadi
Feb 23, 2021·Royal Society Open Science·Thomas SwiftStephen Rimmer
Feb 23, 2021·Frontiers in Pharmacology·Agnese GagliardiDonato Cosco
Mar 19, 2021·Chemical Society Reviews·Yufei XueNicolas Hans Voelcker
Apr 2, 2021·Expert Opinion on Drug Delivery· Neha DesaiAbdelwahab Omri
Apr 13, 2021·Expert Review of Anticancer Therapy·Hanitrarimalala VeroniainaXiaole Qi
Aug 11, 2019·Advanced Drug Delivery Reviews·Joydeb MajumderTamara Minko

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