Polymer-based nanoparticles for chemo/gene-therapy: Evaluation its therapeutic efficacy and toxicity against colorectal carcinoma

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yan ChenHongTao Xiao

Abstract

Combination treatment through simultaneous delivery of anticancer drugs and gene with nano-formulation has been demonstrated to be an elegant and efficient approach for colorectal cancer therapy. Recently, sorafenib being studied in combination therapy in colorectal cancer (CRC) attracted attention of researchers. On the basis of our previous study, pigment epithelium-derived factor (PEDF) loaded nanoparticles showed good effect on CRC in vitro and in vivo. Herein, we designed a combination therapy for sorafenib (Sora), a multi-kinase inhibitor and PEDF, a powerful antiangiogenic gene, in a nano-formulation aimed to increase anti-tumor effect on CRC for the first time. Sora and PEDF were simultaneously encapsulated in PEG-PLGA based nanoparticles by a modified double-emulsion solvent evaporation method. The obtained co-encapsulated nanoparticles (Sora@PEDF-NPs) showed high entrapment efficiency of both Sora and PEDF - and exhibited a uniform spherical morphology. The release profiles of Sora and PEDF were in a sustained manner. The most effective tumor growth inhibition in the C26 cells and C26-bearing mice was observed in the Sora@PEDF-NPs in comparison with none-drug nanoparticles, free Sora, mono-drug nanoparticles (Sora-NPs...Continue Reading

Citations

Jun 28, 2020·AAPS PharmSciTech·Laura CabezaConsolación Melguizo
Sep 17, 2020·Biomedicines·Lavinia SalamaShaker A Mousa
Nov 27, 2020·Cancers·Naomi BrookArun Dharmarajan
Jun 3, 2021·International Journal of Molecular Sciences·Ivan T RebustiniS Patricia Becerra
Aug 11, 2021·Molecular Pharmaceutics·Xueyan ZhangKe Men

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