Polymer coated mucoadhesive liposomes intended for the management of xerostomia

International Journal of Pharmaceutics
M AdamczakMarianne Hiorth

Abstract

The aim of this work was to prepare and test different pharmaceutical formulations in respect of their potential in relieving dry mouth symptom. Since many of the products available on the market provide only temporary relief to the patients, there is need for new formulations able to retain on the oral mucosa. The prolonged moisture protection could be achieved by combining mucoadhesive materials, such as polymers containing hydrogen bonding groups, with vesicles capable of releasing hydration medium from the inner compartment. In this study three different types of liposomes (positively, negatively and neutrally charged) were coated with five different types of polymers: low-methoxylated pectin (LM-pectin), high-methoxylated pectin (HM-pectin), alginate, chitosan and hydrophobically modified ethyl hydroxyethyl cellulose (HM-EHEC). The particle size and the zeta potential of the obtained carriers were tested by measuring dynamic light scattering (DLS) and electrophoretic mobility. Later on, selected positively charged liposomes were deposited on a negatively charged mica surface and depicted by atomic force microscopy (AFM). The water sorption properties of polymers, uncoated liposomes and polymer-coated liposomes were studied...Continue Reading

Citations

Mar 23, 2018·Pharmaceutics·Federica RinaldiCarlotta Marianecci
Sep 12, 2018·Marine Drugs·Irina M YermakViktoria N Davydova
Dec 5, 2020·Journal of Texture Studies·Jing HuAnwesha Sarkar
Sep 14, 2019·Advances in Colloid and Interface Science·Anwesha SarkarSeunghwan Lee
May 29, 2020·ACS Applied Materials & Interfaces·Hongping WanPrashant K Sharma
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira

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