Polymer directed self-assembly of pH-responsive antioxidant nanoparticles

Langmuir : the ACS Journal of Surfaces and Colloids
Christina TangRobert K Prud'homme

Abstract

We have developed pH-responsive, multifunctional nanoparticles based on encapsulation of an antioxidant, tannic acid (TA), using flash nanoprecipitation, a polymer directed self-assembly method. Formation of insoluble coordination complexes of tannic acid and iron during mixing drives nanoparticle assembly. Tuning the core material to polymer ratio, the size of the nanoparticles can be readily tuned between 50 and 265 nm. The resulting nanoparticle is pH-responsive, i.e., stable at pH 7.4 and soluble under acidic conditions due to the nature of the coordination complex. Further, the coordination complex can be coprecipitated with other hydrophobic materials such as therapeutics or imaging agents. For example, coprecipitation with a hydrophobic fluorescent dye creates fluorescent nanoparticles. In vitro, the nanoparticles have low cytotoxicity and show antioxidant activity. Therefore, these particles may facilitate intracellular delivery of antioxidants.

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Citations

Dec 18, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Shih-Jiuan ChiuTeh-Min Hu
Feb 26, 2016·Nanomedicine·Mahdi KarimiMichael R Hamblin
Jan 15, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Mahdi KarimiMichael R Hamblin
Nov 1, 2016·Biomacromolecules·Nikolas T WeissmuellerRobert K Prud'homme
Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
Feb 1, 2018·International Journal of Molecular Sciences·Eswar Kandaswamy, Li Zuo
Aug 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yulu XieDongfeng Chen
Oct 5, 2018·Journal of Biomaterials Science. Polymer Edition·Denial Mahata, Santi M Mandal
Aug 30, 2019·Polymers·Shani L LevitChristina Tang
Dec 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hamed AmaniOmid Akhavan
Jul 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Christina TangRobert K Prud'homme
Dec 10, 2020·International Journal of Molecular Sciences·Shani L LevitChristina Tang
Nov 7, 2017·Journal of Pharmaceutical Sciences·Shani L LevitChristina Tang
Jul 25, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sean AllenEvan Scott
Jul 20, 2021·ACS Applied Materials & Interfaces·Dan MuBing Zhang

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