Polymer-free drug-eluting stents for coronary artery disease

Journal of Interventional Cardiology
Moritz BaquetJulinda Mehilli

Abstract

Polymer-free drug-eluting stents (PF-DES) were designed with the expectation of avoiding late restenosis and thrombosis related to the polymer used in traditional DES platforms. Furthermore, due to similarities with bare metal stents after drug elution, PF-DES has been considered as particularly suitable for patients at high bleeding risk. A variety of PF-DES platforms have been clinically tested. Despite their theoretical advantages, PF platforms showed comparable clinical outcomes with modern permanent- or biodegradable polymer-based DES up to 5 years after implantation. Use of more biocompatible polymers on the modern DES platforms is one of the reasons therefore. Their improved safety profile allows already less intensive antithrombotic regimes after DES. Hence, nowadays PF-DES platforms can be considered as one of many DES options for percutaneous treatment of coronary artery disease.

References

Feb 1, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Rainer WesselyAlbert Schömig
Jun 25, 2005·European Heart Journal·Jörg HausleiterUNKNOWN investigators of the individualizable durg-eluting Stent System to Abrogate Restenosis Project
Jan 5, 2006·Circulation·Julinda MehilliUNKNOWN Intracoronary Stenting and Angiographic Restenosis--Test Equivalence Between 2 Drug-Eluting Stents (ISAR-TEST) Trial Investi
Jun 14, 2008·European Heart Journal·Julinda MehilliUNKNOWN Intracoronary Stenting and Angiographic Restenosis Investigators--Test Efficacy of Rapamycin-eluting Stents with Different P
Jan 31, 2012·Journal of the American College of Cardiology·Didier CarriéJoachim Schofer
Jul 23, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Thomas StiermaierSteffen Desch
May 8, 2014·Circulation. Cardiovascular Interventions·Yoshitaka ShiratoriManel Sabaté
Apr 25, 2015·Journal of the American College of Cardiology·Katrin A FiedlerNikolaus Sarafoff
Oct 16, 2015·The New England Journal of Medicine·Philip UrbanUNKNOWN LEADERS FREE Investigators
May 20, 2016·Circulation. Cardiovascular Interventions·Konstantinos D Rizas, Julinda Mehilli
Nov 4, 2016·Journal of the American College of Cardiology·Philippe GarotUNKNOWN LEADERS FREE Investigators
Dec 14, 2016·The New England Journal of Medicine·C Michael GibsonKeith A Fox
Jan 21, 2017·JACC. Cardiovascular Interventions·Stephen G WorthleyUNKNOWN RevElution Investigators

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Citations

Feb 16, 2019·Circulation. Cardiovascular Interventions·Mauro ChiaritoGiulio G Stefanini
Feb 16, 2019·Circulation. Cardiovascular Interventions·Eric A Secemsky, David E Kandzari
Mar 11, 2020·Expert Review of Medical Devices·Carlo A PivatoGiulio G Stefanini
Apr 17, 2020·Pharmaceutics·Natalia BeshchasnaEcaterina Andronescu
Sep 8, 2020·Future Cardiology·Sarah Mauler-Wittwer, Philippe Garot
Jun 3, 2021·Materials·Alexandru Scafa UdrișteElisabeta Bădilă

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