Abstract
Efficient and controlled delivery of therapeutics to tumor cells is one of the important issues in cancer therapy. In the present work, a series of pH- and temperature-responsive polymer grafted iron oxide nanoparticles were prepared by simple coupling of aminated iron oxide nanoparticle with poly(N-isopropylacrylamide-ran-poly(ethylene glycol) methyl ether acrylate)-block-poly(acrylic acid) (P(NIPA-r-PEGMEA)-b-PAA). For this, three water soluble block polymers were prepared via reversible addition fragmentation transfer (RAFT) polymerization technique. At first, three different block copolymers were prepared by polymerizing mixture of NIPA and PEGMEA (with varying mole ratio) in presence of poly(tert-butyl acrylate) (PtBA) macro chain transfer agent. Subsequently, P(NIPA-r-PEGMEA)-b-PAA copolymers were synthesized by hydrolyzing tert-butyl acrylate groups of the P(NIPA-r-PEGMEA)-b-PtBA copolymers. The resulting polymers were then grafted to iron oxide nanoparticles, and these functionalized nanoparticles were thoroughly characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), zeta potential measurements, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), vibrating sa...Continue Reading
References
Feb 10, 2000·Experimental Cell Research·I G CowellC A Austin
Jun 1, 2006·Journal of the American Chemical Society·Haerim LeeSangyong Jon
Jun 14, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Daisuke MatsukumaTakao Aoyagi
Nov 14, 2006·Biomacromolecules·Jean-François LutzRégis Cartier
Apr 25, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Ravin NarainKannan M Krishnan
Apr 28, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·J L ZhangR D K Misra
Nov 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Shu ChenHui-Zhou Liu
Jun 16, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michiaki KumagaiKazunori Kataoka
Jul 4, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·B ChanteauJ-F Berret
Aug 18, 2009·Journal of the American Chemical Society·Charalambos KaittanisJ Manuel Perez
Mar 9, 2010·Biomacromolecules·Huanli SunZhiyuan Zhong
Sep 15, 2010·Molecular Pharmaceutics·Weiwei GaoOmid C Farokhzad
Feb 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Rui LiuPingyun Feng
Mar 3, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Fatin Nawwab Al-DeenRoss Coppel
Apr 1, 2008·Nanotechnology·Ha-Young LeeXiaoyuan Chen
Jun 11, 2011·Journal of Colloid and Interface Science·Kiyofumi KatagiriKunihito Koumoto
Oct 12, 2011·Journal of the American Chemical Society·Jin-Zhi DuJun Wang
Oct 18, 2011·International Journal of Pharmaceutics·Hongyan TangWuli Yang
Jun 19, 2012·Biomaterials·Yuan-Jia PanChang-Chun Wang
Sep 25, 2012·Colloids and Surfaces. B, Biointerfaces·Jian-Bo QuFang Huang
Mar 9, 2013·The Journal of Physical Chemistry. B·Rakesh BanerjeeDibakar Dhara
Apr 2, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xixue HuXing-Jie Liang
Apr 5, 2013·ACS Applied Materials & Interfaces·Banalata SahooDibakar Dhara
Aug 14, 2013·ACS Applied Materials & Interfaces·Li ZhouJiachang Huang
Jul 2, 2014·Journal of Colloid and Interface Science·Banalata SahooDibakar Dhara
Sep 13, 2014·Nanoscale·Aziliz Hervault, Nguyen Th Kim Thanh
Oct 12, 2015·Journal of Colloid and Interface Science·Rakesh BanerjeeDibakar Dhara
Citations
Aug 2, 2016·Journal of Hazardous Materials·Chunming Su
Mar 11, 2016·Colloids and Surfaces. B, Biointerfaces·Ekta RoyPrashant K Sharma
Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Namita SaxenaCharu Lata Dube