Polymer-lipid hybrid anti-HER2 nanoparticles for targeted salinomycin delivery to HER2-positive breast cancer stem cells and cancer cells

International Journal of Nanomedicine
Jun LiJun Han

Abstract

Breast cancer stem cells (CSCs) are responsible for the initiation, recurrence, and metastasis of breast cancer. Sufficient evidence has established that breast cancer cells can spontaneously turn into breast CSCs. Thus, it is essential to simultaneously target breast CSCs and cancer cells to maximize the efficacy of breast cancer therapy. HER2 has been found to be overexpressed in both breast CSCs and cancer cells. We developed salinomycin-loaded polymer-lipid hybrid anti-HER2 nanoparticles (Sali-NP-HER2) to target both HER2-positive breast CSCs and cancer cells. The antitumor activity of Sali-NP-HER2 constructed by conjugating anti-HER2 antibodies to polymer-lipid salinomycin nanoparticles was evaluated in vitro and in vivo. Sali-NP-HER2 efficiently bound to HER2-positive breast CSCs and cancer cells, resulting in enhanced cytotoxic effects compared with non-targeted nanoparticles or salinomycin. In mice bearing breast cancer xenografts, administration of Sali-NP-HER2 exhibited superior efficacy in inhibiting tumor growth. Sali-NP-HER2 reduced the breast tumorsphere formation rate and the proportion of breast CSCs more effectively than non-targeted nanoparticles or salinomycin alone. Sali-NP-HER2 represents a promising approa...Continue Reading

Citations

Sep 29, 2018·Cancers·Vivek KaushikAnand K V Iyer
Nov 23, 2018·Current Drug Targets·Emma Polonio-AlcaláTeresa Puig
Feb 4, 2021·Acta Pharmaceutica Sinica. B·Hongxia DuanWei Huang
Sep 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ayeskanta MohantyIn-Kyu Park
May 1, 2021·International Journal of Molecular Sciences·Vrinda GoteDhananjay Pal
Dec 29, 2020·Drug Discovery Today·Rakesh Kumar Dhritlahre, Ankit Saneja
Apr 30, 2020·Mini Reviews in Medicinal Chemistry·Abhinay ThakurKamil Kuca
Aug 13, 2021·Frontiers in Oncology·Hui WangFengfeng Cai
Aug 29, 2021·Pharmaceutics·Lucia Ruxandra TefasIoan Tomuță

❮ Previous
Next ❯

Methods Mentioned

BETA
nanoprecipitation
protein assay
dynamic light-scattering
transmission electron microscopy
flow cytometry
xenografts

Software Mentioned

SPSS

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.