Polymer microfluidic chips for electrochemical and biochemical analyses

Electrophoresis
Joël RossierPhilippe E Michel

Abstract

Our recent developments concerning the fabrication of polymer microchips and their applications for biochemical analyses are reviewed. We first describe two methods of fabrication of polymer microfluidic chips, namely UV-laser photoablation and plasma etching that are well suited for the prototyping and mass fabrication of microchannel networks with integrated microelectrodes. These microanalytical systems can be coupled with various detection means including mass spectrometry, and their applications in capillary electrophoresis are presented here. We also present how UV laser photoablation can be used for the patterning of biomolecules on polymer surfaces for generating two-dimensional arrays of microspots to carry out affinity assays. Finally, the use of the microchips for the development of fast affinity and immunological assays with electrochemical detection is presented, demonstrating the potential of these polymer microchips for medical diagnostics and drug discovery.

References

Jul 15, 1997·Analytical Chemistry·R M McCormickH H Hooper
Dec 24, 1997·Analytical Chemistry·L MartynovaW A MacCrehan
Mar 10, 1998·Analytical Chemistry·A T WoolleyR A Mathies
May 27, 1999·Electrophoresis·J S RossierH H Girault
Feb 8, 2000·Analytical Biochemistry·P ArenkovA Mirzabekov
Oct 12, 2000·Analytical Chemistry·S A SoperM C Murphy
Feb 24, 2001·Biosensors & Bioelectronics·B H SchneiderL V Howard
Jan 31, 2002·Analytical Chemistry·T C RohnerH H Girault
Mar 1, 2002·Electrophoresis·Xing-Zheng Wu, Janusz Pawliszyn
Aug 8, 2002·Proteomics·Véronique GobryHubert H Girault
Apr 22, 2004·Lab on a Chip·J S Rossier, H H Girault
Oct 1, 1999·Analytical Chemistry·J S RossierH H Girault

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Citations

Jun 15, 2006·Analytical and Bioanalytical Chemistry·Chantal G Khan Malek
Dec 1, 2006·Analytical and Bioanalytical Chemistry·Daniela HoeggerJoël S Rossier
Nov 9, 2007·Analytical and Bioanalytical Chemistry·Holger Becker, Claudia Gärtner
Apr 2, 2010·Annals of Biomedical Engineering·Yan XuKazuhiko Ishihara
Oct 10, 2007·Veterinary Research Communications·E Bollo
Apr 23, 2004·Current Opinion in Biotechnology·Niels LionJoël S Rossier
Apr 22, 2004·Journal of Immunological Methods·Zong DaiHuangxian Ju
Oct 11, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Katri HuikkoTapio Kotiaho
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·W S B YeungJ P Ou
Feb 26, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Justin S MecomberPatrick A Limbach
Sep 28, 2010·Nature Nanotechnology·Jae K HwangMyung M Sung
Oct 30, 2009·Lab on a Chip·Steven SunAvraham Rasooly
Jun 15, 2010·Lab on a Chip·Steven SunAvraham Rasooly
Sep 8, 2011·Journal of Biomedical Optics·Jing Wu, Min Gu
Oct 30, 2007·Journal of Chromatography. a·Evandro PiccinEmanuel Carrilho
Dec 26, 2006·Colloids and Surfaces. B, Biointerfaces·Bin WangJ Hugh Horton
Apr 20, 2005·Journal of Separation Science·David A BarrettMartyn C Davies
Nov 27, 2004·Electrophoresis·Walter R VandaveerSusan M Lunte
Nov 27, 2004·Electrophoresis·Claudimir L do LagoJosé A Fracassi da Silva
Apr 18, 2009·Journal of Mass Spectrometry : JMS·Jeonghoon LeeKermit K Murray
Jan 9, 2009·Electrophoresis·Yun ChenGang Chen
Jul 22, 2004·Analytical Biochemistry·J JenkinsS Sundaram
Mar 7, 2006·Current Opinion in Chemical Biology·Lindy Murphy
Feb 14, 2006·Biosensors & Bioelectronics·Steven A SoperDavid Wilson

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