Polymer nanocomposite particles of S-nitrosoglutathione: A suitable formulation for protection and sustained oral delivery

International Journal of Pharmaceutics
Wen WuAnne Sapin-Minet

Abstract

S-nitrosoglutathione (GSNO) is a nitric oxide (NO) donor with therapeutic potential for cardiovascular disease treatment. Chronic oral treatment with GSNO is limited by high drug sensitivity to the environment and limited oral bioavailability, requiring the development of delivery systems able to sustain NO release. The present work describes new platforms based on polymer nanocomposite particles for the delivery of GSNO. Five types of optimized nanocomposite particles have been developed (three based on chitosan, two based on alginate sodium). Those nanocomposite particles encapsulate GSNO with high efficiency from 64% to 70% and an average size of 13 to 61 μm compatible with oral delivery. Sustained release of GSNO in vitro was achieved. Indeed, chitosan nanocomposites discharged their payload within 24h; whereas alginate nanocomposites released GSNO more slowly (10% of GSNO was still remaining in the dosage form after 24h). Their cytocompatibility toward intestinal Caco-2 cells (MTT assay) was acceptable (IC50: 6.07 ± 0.07-9.46 ± 0.08 mg/mL), demonstrating their suitability as oral delivery systems for GSNO. These delivery systems presented efficient GSNO loading and sustained release as well as cytocompatibility, showing th...Continue Reading

References

Nov 1, 1992·British Journal of Pharmacology·M W RadomskiS Moncada
May 20, 1999·International Journal of Pharmaceutics·V DodaneJ R Merwin
Nov 7, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·G D RosaF Quaglia
Nov 24, 2001·Advanced Drug Delivery Reviews·M ThanouH E Junginger
Jul 20, 2002·Clinical Pharmacokinetics·Hao ZhangJames B Streisand
Apr 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J C G RottaA C Tedesco
Nov 9, 2004·Biomacromolecules·Hong ZhangEugenia Kumacheva
Feb 24, 2006·International Journal of Pharmaceutics·Sakchai Wittaya-areekulChureerat Prahsarn
Jul 11, 2006·International Journal of Pharmaceutics·Srisagul SungthongjeenSatit Puttipipatkhachorn
Feb 13, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Amol J Thote, Ram B Gupta
Apr 24, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·T P AmadeuA M A Costa
Jul 24, 2007·International Journal of Pharmaceutics·A Sheikh HasanN Ubrich
Apr 1, 2008·The Journal of Surgical Research·Thaís P AmadeuAndréa Monte-Alto-Costa
May 1, 2008·AAPS PharmSciTech·Praneet OpanasopitUracha Ruktanonchai
Sep 27, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yu-Hsin LinHsing-Wen Sung
Mar 11, 2010·Advanced Materials·Peter DomachukDavid L Kaplan
Jul 31, 2012·International Journal of Pharmaceutics·Ioannis A SogiasVitaliy V Khutoryanskiy
Feb 19, 2013·Biochimica Et Biophysica Acta·Katarzyna A BroniowskaNeil Hogg
Aug 13, 2013·Expert Opinion on Drug Delivery·Takayuki YoshidaKazuhiro Sako
Nov 15, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Lianjiang TanHuili Li
Mar 15, 2014·European Journal of Pharmacology·Fatima DahboulPierre Leroy
Dec 3, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wen WuAnne Sapin-Minet
Mar 27, 2015·Journal of Biomedical Materials Research. Part a·Marianne ParentCaroline Gaucher

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Citations

Jul 11, 2016·The International Journal of Biochemistry & Cell Biology·Marek RychterJanina Lulek
Oct 25, 2016·Nitric Oxide : Biology and Chemistry·Halley C OliveiraAmedea B Seabra
Apr 1, 2018·Arhiv za higijenu rada i toksikologiju·Kristina Dominko, Domagoj Đikić
Aug 11, 2020·Nitric Oxide : Biology and Chemistry·Yi ZhouMarianne Parent
Oct 30, 2021·ACS Applied Materials & Interfaces·Yun QianElizabeth J Brisbois

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