Polymer Nanocontainers for Intracellular Delivery

Angewandte Chemie
Sharafudheen Pottanam Chali, Bart Jan Ravoo

Abstract

Carriers for intracellular delivery are required to overcome limitations of therapeutic agents such as low specificity, systemic toxicity, high clearance rate, and low therapeutic index. Nanocontainers comprised of an aqueous core and a polymer shell have received increasing attention because they readily combine stimuli response to improve intracellular payload release and surface modification to enhance selectivity towards the desired region of action. This Minireview summarizes the design and properties of polymer nanocontainers for intracellular delivery, classified according to the polymer architecture.

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Citations

Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Søren Mejlsøe, Ashok Kakkar
Feb 15, 2020·Nanoscale·Yiseul RyuHak-Sung Kim
Nov 30, 2019·Soft Matter·Raju BejSuhrit Ghosh
Jun 14, 2020·Angewandte Chemie·Jingxin ShaoJan C M van Hest
Feb 5, 2021·Advanced Drug Delivery Reviews·Will Stuart-Walker, Clare S Mahon
Aug 3, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Esther Amstad, Matthew J Harrington
Jun 15, 2021·Chemistry : a European Journal·Sharafudheen Pottanam ChaliBart Jan Ravoo
Aug 24, 2021·Advanced Science·Meng ZhengBingyang Shi
Apr 10, 2020·ACS Applied Materials & Interfaces·Baiju P KrishnanJiaxi Cui
Sep 4, 2021·ACS Nano·Sangpil KimJa-Hyoung Ryu
Oct 28, 2021·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Andrea L J Marschall

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Methods Mentioned

BETA
AFM
fluorescence imaging
PMA

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