Polymer nanostructures synthesized by controlled living polymerization for tumor-targeted drug delivery

Journal of Controlled Release : Official Journal of the Controlled Release Society
Christine E WangAnthony J Convertine

Abstract

The development of drug delivery systems based on well-defined polymer nanostructures could lead to significant improvements in the treatment of cancer. The design of these therapeutic nanosystems must account for numerous systemic and circulation obstacles as well as the specific pathophysiology of the tumor. Nanoparticle size and surface charge must also be carefully selected in order to maintain long circulation times, allow tumor penetration, and avoid clearance by the reticuloendothelial system (RES). Targeting ligands such as vitamins, peptides, and antibodies can improve the accumulation of nanoparticle-based therapies in tumor tissue but must be optimized to allow for intratumoral penetration. In this review, we will highlight factors influencing the design of nanoparticle therapies as well as the development of modern controlled "living" polymerization techniques (e.g. ATRP, RAFT, ROMP) that are leading to the creation of sophisticated new polymer architectures with discrete spatially-defined functional modules. These innovative materials (e.g. star polymers, polymer brushes, macrocyclic polymers, and hyperbranched polymers) combine many of the desirable properties of traditional nanoparticle therapies while substantia...Continue Reading

References

Jan 1, 1987·Cancer Metastasis Reviews·R K Jain
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·N A PeppasA M Lowman
Apr 7, 2000·The American Journal of Pathology·H HashizumeD M McDonald
Mar 17, 2001·Advanced Drug Delivery Reviews·K KataokaY Nagasaki
Dec 26, 2001·Chemical Reviews·K Matyjaszewski, J Xia
May 16, 2002·Bioconjugate Chemistry·Omayra L Padilla De JesúsFrancis C Szoka
Sep 3, 2002·Advanced Drug Delivery Reviews·Yingjuan Lu, Philip S Low
Sep 21, 2002·Science·Christopher W BielawskiRobert H Grubbs
Jun 5, 2003·Nature Biotechnology·Svetlana O DoroninaPeter D Senter
Mar 30, 2005·Nano Letters·Eun Seong LeeYou Han Bae
Sep 28, 2005·International Journal of Cancer. Journal International Du Cancer·Ying ChauRobert Langer
Mar 30, 2006·Journal of the American Chemical Society·Boyd A Laurent, Scott M Grayson
Jul 25, 2006·Nature Reviews. Cancer·Andrew I Minchinton, Ian F Tannock
Aug 11, 2006·Nature Reviews. Cancer·Ruth Duncan
Aug 29, 2006·Drug Discovery Today·Arun K IyerHiroshi Maeda
Aug 31, 2006·Journal of the American Chemical Society·Michael R WhittakerMichael J Monteiro
Jun 15, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Suhrit GhoshS Thayumanavan
Oct 30, 2007·Journal of the American Chemical Society·Steven J P'Pool, Hans-Jörg Schanz
Feb 9, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Hongtao ChenJi-Xin Cheng
Sep 2, 2008·Nature Reviews. Drug Discovery·Mark E DavisDong M Shin
Mar 5, 2009·Journal of the American Chemical Society·Norased NasongklaFrancis C Szoka
Apr 7, 2009·Nano Letters·Steven D PerraultWarren C W Chan
May 26, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bo ChenFrancis C Szoka
Sep 22, 2009·Chemical Reviews·Cyrille BoyerSébastien Perrier
Mar 24, 2010·Chemical Society Reviews·Charles E HoyleChristopher N Bowman
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Jun 28, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Emily CrownoverPatrick S Stayton
Aug 20, 2011·Biochimica Et Biophysica Acta·Tracy R DanielsManuel L Penichet
Sep 29, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Twan LammersGert Storm
Mar 9, 2012·Theranostics·Ki Young ChoiXiaoyuan Chen
Mar 13, 2012·The AAPS Journal·Neil Desai
Apr 27, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ines BeyerAndré Lieber
Jul 10, 2012·Biomaterials·Eun-Ho SongDaniel M Ratner
Aug 10, 2013·Science·Jean-François LutzMitsuo Sawamoto
Sep 26, 2013·Advanced Drug Delivery Reviews·Yuanpei LiKit S Lam
Oct 1, 2013·Nature Communications·Guillaume GodySébastien Perrier

❮ Previous
Next ❯

Citations

Apr 6, 2017·Macromolecular Bioscience·Amaya Niño-ParienteMaría J Vicent
Jul 12, 2017·Pharmaceutical Patent Analyst·Hermann Am Mucke
Oct 29, 2018·Advanced Healthcare Materials·Daniel C LeeSuzie H Pun
Sep 20, 2018·Current Drug Metabolism·Vivek K ChaturvediMohan P Singh
Jan 18, 2020·Nanoscale Research Letters·Yumiao HeChao Ma
Aug 1, 2020·Advanced Drug Delivery Reviews·Jindřich Kopeček, Jiyuan Yang
Jun 27, 2020·Advanced Drug Delivery Reviews·Kaitlyn SadtlerRobert Langer
Aug 24, 2019·Seminars in Cancer Biology·Abul BarkatFarhan J Ahmed
Feb 9, 2021·Biomacromolecules·Johanna K ElterFelix H Schacher
Apr 4, 2021·Gels·Emanuele MauriAlberto Rainer
Mar 21, 2020·Journal of the American Chemical Society·Shixian LvJianjun Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Chung Hang J ChoiMark E Davis
© 2021 Meta ULC. All rights reserved