Polymer surface interacts with calcium in aqueous media to induce stem cell assembly

Advanced Healthcare Materials
Kun-Che Hung, Shan-Hui Hsu

Abstract

Bioinspired surface with functional group rearrangement abilities are highly desirable for designing functional materials. Calcium ion (Ca(2+) ) is a pivotal life element and the ion transport is tightly regulated through calcium channels. It is demonstrated here that Ca(2+) can be transported by polymer surface to induce cell assembly. A series of polyurethane materials is synthesized with different abilities to rearrange the surface functional groups in response to aqueous environment. It is observed that surface recruitment of carboxyl and amino groups from the bulk material can interact with Ca(2+) and facilitate its translocation from aqueous media into cells. The surface rearrangement of functional group triggers the calcium trafficking and turns on signals involving cell merging and assembly. This observation provides an insight on adjusting material-calcium interaction to design nature-inspired smart interfaces to induce cell organization and tissue regeneration.

References

Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·W CaoR Waser
Apr 1, 2003·Molecular and Cellular Biology·Alain Lilienbaum, Alain Israël
May 27, 2006·European Cells & Materials·D WideraB Kaltschmidt
Dec 18, 2007·Cell·David E Clapham
Jan 24, 2008·Reproductive Sciences·Valentina CascianiJohn R G Challis
Feb 6, 2008·Journal of Tissue Engineering and Regenerative Medicine·Mohamadreza Baghaban EslaminejadAghbibi Nickmahzar
Feb 11, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mohamadreza Baghaban EslaminejadHouri Mivehchi
May 15, 2012·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sumaiya Hasnain, Nahid Nishat
Jun 5, 2012·Trends in Cell Biology·Azucena Ramos, Fernando D Camargo
Jul 17, 2012·Journal of Cell Science·Brendon M Baker, Christopher S Chen
Sep 18, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Nataly BelmanNoshir S Pesika
Jan 1, 2014·Journal of Biomedical Materials Research. Part a·Marija V PergalJasna Djonlagić
Feb 22, 2014·Nature Reviews. Molecular Cell Biology·Kirsty Minton
Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Wen-Cheng ChenHsien-Nan Kuo
Jul 30, 2014·Nature Materials·B Kollbe AhnJ Herbert Waite
Aug 19, 2014·Journal of Biomedical Materials Research. Part a·Ling E LingYan Lv
Oct 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lijing HaoYingjun Wang
Aug 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shan-Hui HsuJui-Che Lin

❮ Previous
Next ❯

Citations

Nov 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hsin-Hua LinShan-Hui Hsu
Apr 1, 2017·Advanced Biosystems·Rui-Xin WuFa-Ming Chen
Dec 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shan-Hui HsuYi-Ming Sun
Aug 14, 2019·ACS Applied Materials & Interfaces·Cheng-Tien Hsieh, Shan-Hui Hsu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

BMJ : British Medical Journal
Richard Cookson
Nature Chemical Biology
Laura Furst, Corey R J Stephenson
© 2021 Meta ULC. All rights reserved