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Polymerase ? activity is linked to replication timing in humans: evidence from mutational signatures

bioRxiv

Nov 17, 2014

Vladimir B. SeplyarskiyRuslan A. Soldatov

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Abstract

Replication timing is an important determinant of germline mutation patterns, with a higher rate of point mutations in late replicating regions. Mechanisms underlying this association remain elusive. One of the suggested explanations is the activity of error-prone DNA polymerases in lat...read more

Mentioned in this Paper

Dinucleoside Phosphates
Study
Transverse - Anatomical Location
Mutation Abnormality
Genome
Virus Replication
Point Mutation
Patterns
Research Study
Malignant Neoplasm of Stomach
8
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  • Polymerase ? activity is linked to replication timing in humans: evidence from mutational signatures

    bioRxiv

    Nov 17, 2014

    Vladimir B. SeplyarskiyRuslan A. Soldatov

    PMID: 990011494

    DOI: 10.1101/011494

    Abstract

    Replication timing is an important determinant of germline mutation patterns, with a higher rate of point mutations in late replicating regions. Mechanisms underlying this association remain elusive. One of the suggested explanations is the activity of error-prone DNA polymerases in lat...read more

    Mentioned in this Paper

    Dinucleoside Phosphates
    Study
    Transverse - Anatomical Location
    Mutation Abnormality
    Genome
    8

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