Polymeric and Solid Lipid Nanoparticles for Sustained Release of Carbendazim and Tebuconazole in Agricultural Applications

Scientific Reports
Estefânia Vangelie Ramos CamposLeonardo F Fraceto

Abstract

Carbendazim (MBC) (methyl-2-benzimidazole carbamate) and tebuconazole (TBZ) ((RS)-1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol) are widely used in agriculture for the prevention and control of fungal diseases. Solid lipid nanoparticles and polymeric nanocapsules are carrier systems that offer advantages including changes in the release profiles of bioactive compounds and their transfer to the site of action, reduced losses due to leaching or degradation, and decreased toxicity in the environment and humans. The objective of this study was to prepare these two types of nanoparticle as carrier systems for a combination of TBZ and MBC, and then investigate the release profiles of the fungicides as well as the stabilities and cytotoxicities of the formulations. Both nanoparticle systems presented high association efficiency (>99%), indicating good interaction between the fungicides and the nanoparticles. The release profiles of MBC and TBZ were modified when the compounds were loaded in the nanoparticles, and cytotoxicity assays showed that encapsulation of the fungicides decreased their toxicity. These fungicide systems offer new options for the treatment and prevention of fungal diseases in plants.

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Citations

May 18, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Eameema MuntimaduguWahid Khan
Aug 31, 2016·Colloids and Surfaces. B, Biointerfaces·Estefânia V R CamposLeonardo F Fraceto
Oct 26, 2016·Chemistry and Physics of Lipids·Sandeep KumarKi-Hyun Kim
Feb 1, 2019·Journal of Microencapsulation·Sunita Lahkar, Malay Kumar Das
Jan 24, 2019·Pest Management Science·Maurizio VurroAlejandro Pérez-de-Luque
Nov 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Javier Pérez QuiñonesOliver Brüggemann
Apr 20, 2017·Frontiers in Plant Science·Sandhya MishraHarikesh Bahadur Singh
Jan 28, 2021·Nanomaterials·Anderson do Espirito Santo PereiraCatherine Santaella
Mar 6, 2019·Carbohydrate Polymers·Sathiyabama MuthukrishnanMuthukumar Selvaraj
Jun 12, 2021·Frontiers in Chemistry·Mukesh MeenaPriyankaraj Sonigra
Aug 16, 2017·Journal of Agricultural and Food Chemistry·Amir E KaziemJianhong Li
Jul 24, 2018·Journal of Agricultural and Food Chemistry·Gauri A Achari, Meenal Kowshik
Aug 20, 2021·Frontiers in Plant Science·Mulla S AyeshaRamanan Uma Shaanker

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Methods Mentioned

BETA
genetic modifications
transmission electron microscopy

Software Mentioned

Galaxy Workstation
NanoSight

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