Polymeric black tea polyphenols inhibit mouse skin chemical carcinogenesis by decreasing cell proliferation.

Cell Proliferation
Rachana PatelGirish B Maru

Abstract

The aim of this study was to investigate the antitumour promoting effects and possible mechanisms of action of the most abundant polymeric black tea polyphenols (PBPs 1-5) or thearubigins, in vivo. Effect of PBP pre-treatments on 12-O-tetradecanoylphorbol-13-acetate (TPA) promoted skin papillomas was studied in 7,12-dimethylbenz(a)anthracene initiated mice over 40 weeks. Cell proliferation and apoptosis, in epidermis of the skin, were measured using appropriate immunohistochemical staining. Mitogen-activated protein kinase signalling studies were conducted with Western blot analysis at 10, 20, 30 and 40 weeks of promotion. Pre-treatments with PBP fractions differentially altered latency, multiplicity and incidence of skin papillomas as compared to TPA treatments thereby exhibiting antipromoting effects. Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2). TPA-induced epidermal cell apoptosis was also decreased by pre-treatment with most PBP fractions. H...Continue Reading

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Citations

Aug 8, 2009·Bioscience, Biotechnology, and Biochemistry·Carsten MüllerPablo Steinberg
May 30, 2013·International Journal of Nanomedicine·Amit Kumar SrivastavaKailash Chand Gupta
Oct 31, 2012·Cancer Epidemiology·Andy H LeeColin W Binns
Jan 3, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Gudrun Ulrich-MerzenichKarin Kraft
Sep 11, 2008·Expert Opinion on Therapeutic Targets·Katrina MacAulay, James R Woodgett
Nov 17, 2014·Molecular and Cellular Biochemistry·Ferial MajedSarwat Sultana
Aug 30, 2008·International Journal of Cancer. Journal International Du Cancer·Samrat T KunduSorab N Dalal

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