Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

Polymers
Magdalena ZiębaGrazyna Adamus

Abstract

Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

References

Apr 1, 1979·Journal of Clinical Periodontology·J M GoodsonS S Socransky
Jun 1, 1979·Journal of Clinical Periodontology·J LindheS S Socransky
Oct 1, 1992·Calcified Tissue International·C H ChungI M Shapiro
May 1, 1985·Journal of Periodontology·J M GoodsonP E Hogan
Oct 1, 1983·Journal of Periodontology·J M GoodsonS Dunham
Feb 20, 1998·Chemical & Pharmaceutical Bulletin·T NakanishiM Hayashi
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K Schwach-AbdellaouiR Gurny
May 24, 2001·Journal of Bacteriology·B J PasterF E Dewhirst
Apr 25, 2003·Journal of Periodontology·D T Graves, D Cochran
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jun 28, 2003·Journal of Periodontal Research·Tania CrottiDavid Haynes
Jun 23, 2004·Journal of Periodontal Research·Qian LuLakshman P Samaranayake
Jun 23, 2004·Journal of Periodontal Research·Lei RenW Keung Leung
Apr 9, 2005·International Journal of Pharmaceutics·E Piñón-SegundoD Quintanar-Guerrero
Aug 6, 2005·Journal of Clinical Microbiology·Purnima S KumarEugene J Leys
Sep 24, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hui ZengAndrew S Neish
Dec 8, 2005·Journal of Periodontology·Poul Erik Petersen, Hiroshi Ogawa
Mar 21, 2006·Advanced Drug Delivery Reviews·Ghanashyam Acharya, Kinam Park
Apr 4, 2006·Environmental Health Perspectives·Darryl C ZeldinDavid Peden
Nov 14, 2006·Advanced Drug Delivery Reviews·Davis Yohanes ArifinChi-Hwa Wang
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elia BurnsGabriel Nussbaum
Jun 2, 2007·Journal of Periodontology·Nawarat Wara-aswapatiWaranuch Pitiphat
Feb 29, 2008·Cytokine·Yong-Chen LuPamela S Ohashi
Sep 4, 2008·Journal of Periodontology·David L Cochran
Aug 8, 2008·Journal of Drug Targeting·Yvonne Perrie
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·George HajishengallisKathy Triantafilou
Sep 16, 2008·Drug Discovery Today·Nilu JainRoop K Khar
Mar 27, 2009·Journal of Materials Science. Materials in Medicine·Qiu Xia JiLing Chong Wang
Feb 11, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maedeh ZamaniMarziyeh Jannesari
Jun 2, 2010·Nature Reviews. Microbiology·Richard P Darveau
Jul 29, 2010·Biomaterials·Daniela F CoutinhoRui L Reis

❮ Previous
Next ❯

Citations

Jan 10, 2021·Pharmaceutics·Daniela Placha, Josef Jampilek
Mar 27, 2021·Drug Delivery and Translational Research·Sevda ŞenelGülçin Akca
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola d'AvanzoMassimo Fresta
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicolae BaranovDaniela Luminita Ichim
Aug 18, 2021·Biomaterials·Mayuka NakajimaSamir Mitragotri

❮ Previous
Next ❯

Methods Mentioned

BETA
dynamic light scattering
ELISA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Stem Cells
Su-Hwan KimYong-Moo Lee
Advances in Experimental Medicine and Biology
Antonio Bascones-MartínezCristina Bascones-Ilundáin
© 2021 Meta ULC. All rights reserved