Polymeric drugs derived from ibuprofen with improved antiinflammatory profile

Journal of Biomedical Materials Research
P A LisoA M Villar

Abstract

A new methacrylic monomeric compound bearing Ibuprofen (MIA) and the respective polymethacrylic macromolecular derivative (polyMIA) were evaluated for antiinflammatory properties in order to study their pharmacological activity profile. The macromolecular drug is constituted of Ibuprofen residues linked covalently to a polymethacrylic support, as a side substituent of the repeating unit, by means of a spacer group (p-aminophenoxy) that, in addition, is the most representative metabolite of Paracetamol. The Ibuprofen is slowly released from the polymeric support by hydrolysis of the ester bond in a biological medium. Different antiinflammatory testing methods were used; and the results obtained indicate that the monomeric and polymeric forms display higher potency to inhibit acute inflammatory processes than the traditional Ibuprofen form, even doubling the power of Ibuprofen. In addition, they present higher activity against chronic experimental processes, as well as an excellent antinociceptive behavior to inhibit the pain associated with arthritic diseases. According to previous reports and results presented in this article, we can conclude that the new polymethacrylic structures show higher analgesic, antipiretic, and antiin...Continue Reading

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Citations

Apr 25, 2006·The Journal of Craniofacial Surgery·Mohamed Al MalyanNureddin Ashammakhi
Apr 13, 2018·International Journal of Molecular Sciences·Anna PawełczykLucjusz Zaprutko
May 21, 2011·Pharmaceutical Biology·María I AguilarAndrés Navarrete

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