Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers

Angewandte Chemie
Johannes KargesGilles Gasser

Abstract

The use of photodynamic therapy (PDT) to treat cancer has received increasing attention over the last years. However, the clinically used photosensitisers (PSs) have some limitations that include poor aqueous solubility, hepatotoxicity, photobleaching, aggregation, and slow clearance from the body, so the design of new classes of PSs is of great interest. We present the use of bis(dipyrrinato)zinc(II) complexes with exceptionally long lifetimes as efficient PDT PSs. Based on the heavy-atom effect, intersystem crossing of these complexes changes the excited state from singlet to a triplet state, thereby enabling singlet oxygen generation. To overcome the limitation of quenching effects in water and improve water solubility, the lead compound 3 was encapsulated in a polymer matrix. It showed impressive phototoxicity upon irradiation at 500 nm in various monolayer cancer cells as well as 3D multicellular tumour spheroids, without observed dark toxicity.

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Citations

Jun 28, 2020·Nature Communications·Johannes KargesGilles Gasser
Nov 5, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Johannes KargesGilles Gasser
Dec 9, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Arnab BhattacharyyaAkhil R Chakravarty
Apr 30, 2021·European Journal of Medicinal Chemistry·Arnab BhattacharyyaAkhil R Chakravarty
May 14, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Chao ZhangQianxiong Zhou
Jun 2, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pinghua LingFeng Gao
Jun 25, 2021·Chemical Science·Vinayak JuvekarHwan Myung Kim
Sep 2, 2020·Journal of the American Chemical Society·Wei-Jian LiHai-Bo Yang
Mar 17, 2020·Journal of the American Chemical Society·Johannes KargesGilles Gasser
Nov 11, 2021·Chemistry : a European Journal·Zhongxian FanHuaiyi Huang

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