Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery Systems

Scientific Reports
Beatrice FortuniHiroshi Uji-I

Abstract

Most targeting strategies of anticancer drug delivery systems (DDSs) rely on the surface functionalization of nanocarriers with specific ligands, which trigger the internalization in cancer cells via receptor-mediated endocytosis. The endocytosis implies the entrapment of DDSs in acidic vesicles (endosomes and lysosomes) and their eventual ejection by exocytosis. This process, intrinsic to eukaryotic cells, is one of the main drawbacks of DDSs because it reduces the drug bioavailability in the intracellular environment. The escape of DDSs from the acidic vesicles is, therefore, crucial to enhance the therapeutic performance at low drug dose. To this end, we developed a multifunctionalized DDS that combines high specificity towards cancer cells with endosomal escape capabilities. Doxorubicin-loaded mesoporous silica nanoparticles were functionalized with polyethylenimine, a polymer commonly used to induce endosomal rupture, and hyaluronic acid, which binds to CD44 receptors, overexpressed in cancer cells. We show irrefutable proof that the developed DDS can escape the endosomal pathway upon polymeric functionalization. Interestingly, the combination of the two polymers resulted in higher endosomal escape efficiency than the poly...Continue Reading

References

Jan 1, 1997·Advances in Cancer Research·D NaorD Ish-Shalom
Feb 17, 1998·Biochemical Pharmacology·R Regev, G D Eytan
Aug 13, 1998·Biophysical Chemistry·K K KarukstisR J Rosenfeld
Apr 25, 2001·The Journal of Gene Medicine·A KichlerO Danos
Dec 18, 2001·Advanced Drug Delivery Reviews·R KircheisE Wagner
Jun 9, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·U LungwitzA Göpferich
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Jun 21, 2006·Dermatologic Therapy·Gary D Monheit, Kyle M Coleman
Jun 25, 2009·Current Medicinal Chemistry·Cristina CarvalhoPaula I Moreira
Sep 29, 2009·Biomaterials·Ki Young ChoiSeo Young Jeong
May 1, 2007·Nanobiotechnology : the Journal at the Intersection of Nanotechnology, Molecular Biology, and Biomedical Sciences·Jie LuFuyuhiko Tamanoi
Aug 20, 2010·Journal of the American Chemical Society·Huan MengAndre E Nel
Sep 17, 2010·Biochemistry·Anoma SomasunderamDavid G Gorenstein
Dec 17, 2010·The New England Journal of Medicine·Betty Y S KimWarren C W Chan
Jan 7, 2011·American Journal of Physiology. Cell Physiology·Kenneth W DunnJohn H McDonald
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen
Mar 24, 2012·Chemical Society Reviews·Piaoping YangJun Lin
Aug 7, 2012·Macromolecular Bioscience·Katherine A GibneyKenichi Kuroda
Oct 4, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Rikke V BenjaminsenThomas L Andresen
Jan 3, 2013·The Journal of Pharmacy and Pharmacology·Oktay TacarCrispin R Dass
Jan 11, 2013·Chemistry : a European Journal·Zhaowei ChenXiaogang Qu
Jun 25, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Silvia ArpiccoMarta Palmieri
May 21, 2014·Pharmaceutical Research·Shuangshuang SongWeisan Pan
Dec 3, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Ying WangSiling Wang

❮ Previous
Next ❯

Citations

Aug 18, 2020·Future Oncology·Harshita Abul BarkatHazrina Ab Hadi
Nov 27, 2019·Cancers·Lucia SalvioniDavide Prosperi
Aug 22, 2020·International Journal of Nanomedicine·Kyungeun Kim, Dongwoo Khang
Jan 19, 2021·Macromolecular Bioscience·Liliana Aranda-LaraEnrique Morales-Avila
Oct 9, 2019·Journal of Colloid and Interface Science·Saurabh K MauryaJérôme F L Duval
Jan 27, 2021·Journal of Cell Science·Giulia PaciEdward A Lemke
Jan 1, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jing-Bo MaXiao-Li Zhang
Nov 15, 2020·Nanomaterials·Indra Van ZundertSusana Rocha
Dec 10, 2020·International Journal of Molecular Sciences·Darío ManzanaresValentín Ceña
May 7, 2020·ACS Applied Materials & Interfaces·Giuseppe CavallaroYuri Lvov
Mar 20, 2021·Macromolecular Bioscience·Asim MushtaqLisbeth Grøndahl
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alicia J SawdonChing-An Peng
Apr 4, 2021·International Journal of Molecular Sciences·Banendu Sunder DashJyh-Ping Chen
Apr 24, 2021·Expert Opinion on Drug Delivery·Seyed Mehdi Kamali ShahriMorteza Mahmoudi
May 1, 2021·Nanomaterials·Alena Opálková ŠiškováAnita Eckstein Andicsová
May 13, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kuan-Ju ChenDavid Cipolla
Jun 15, 2021·Frontiers in Plant Science·Sunny AhmarKi-Hung Jung
Jul 3, 2021·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin
Dec 6, 2019·ACS Applied Materials & Interfaces·Delyan R HristovDavid J Brayden
Aug 26, 2021·Journal of Cell Science·Giulia PaciEdward A Lemke
Aug 28, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·G RomoliniL Latterini
Oct 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Nikunjkumar R Visaveliya, J Michael Köhler
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Marjan MotieiSeyede Zohreh Mirahmadi-Zare

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
fluorescence microscopy
scanning electron microscopy
Fluorescence
electron microscopy
transmission electron microscopy

Software Mentioned

MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.