Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents

Chemical Science
Lyndsay M RandolphNathan C Gianneschi

Abstract

A Gd3+-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior in vivo, intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

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Citations

Oct 13, 2017·Small·Zhao WangNathan C Gianneschi
Aug 5, 2016·Chemistry : a European Journal·Javier Aríñez-SorianoDaniel Maspoch
Sep 9, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Juan PellicoFernando Herranz

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Methods Mentioned

BETA
electron microscopy
transmission electron microscopy
X-ray
nuclear magnetic resonance
nuclear magnetic relaxation

Software Mentioned

Exova

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