Polymeric micelles and nanoemulsions as tumor-targeted drug carriers: Insight through intravital imaging

Journal of Controlled Release : Official Journal of the Controlled Release Society
Natalya Y RapoportBrian E O'Neill

Abstract

Intravital imaging of nanoparticle extravasation and tumor accumulation has revealed, for the first time, detailed features of carrier and drug behavior in circulation and tissue that suggest new directions for optimization of drug nanocarriers. Using intravital fluorescent microscopy, the extent of the extravasation, diffusion in the tissue, internalization by tissue cells, and uptake by the RES system were studied for polymeric micelles, nanoemulsions, and nanoemulsion-encapsulated drug. Discrimination of vascular and tissue compartments in the processes of micelle and nanodroplet extravasation and tissue accumulation was possible. A simple 1-D continuum model was suggested that allowed discriminating between various kinetic regimes of nanocarrier (or released drug) internalization in tumors of various sizes and cell density. The extravasation and tumor cell internalization occurred much faster for polymeric micelles than for nanoemulsion droplets. Fast micelle internalization resulted in the formation of a perivascular fluorescent coating around blood vessels. A new mechanism of micelle extravasation and internalization was suggested, based on the fast extravasation and internalization rates of copolymer unimers while mainta...Continue Reading

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Citations

Nov 19, 2015·Journal of Biomaterials Science. Polymer Edition·Fang WangQinwei Gao
Jun 21, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Roohi GuptaNatalya Rapoport
Apr 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kinam Park
Jun 9, 2016·Advanced Drug Delivery Reviews·Miles A Miller, Ralph Weissleder
Dec 13, 2016·Chemical Society Reviews·Xianfeng Chen, Wenjun Zhang
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Oct 31, 2020·International Journal of Nanomedicine·Lauren E CosbyJessica O Winter
Apr 17, 2021·ACS Pharmacology & Translational Science·Nahid S AwadGhaleb A Husseini

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