Polymeric micelles for potentiated antiulcer and anticancer activities of naringin

International Journal of Nanomedicine
Elham Abdelmonem MohamedFarid Abd Elreheem Badria

Abstract

Naringin is one of the most interesting phytopharmaceuticals that has been widely investigated for various biological actions. Yet, its low water solubility, limited permeability, and suboptimal bioavailability limited its use. Therefore, in this study, polymeric micelles of naringin based on pluronic F68 (PF68) were developed, fully characterized, and optimized. The optimized formula was investigated regarding in vitro release, storage stability, and in vitro cytotoxicity vs different cell lines. Also, cytoprotection against ethanol-induced ulcer in rats and antitumor activity against Ehrlich ascites carcinoma in mice were investigated. Nanoscopic and nearly spherical 1:50 micelles with the mean diameter of 74.80±6.56 nm and narrow size distribution were obtained. These micelles showed the highest entrapment efficiency (EE%; 96.14±2.29). The micelles exhibited prolonged release up to 48 vs 10 h for free naringin. The stability of micelles was confirmed by insignificant changes in drug entrapment, particle size, and retention (%) (91.99±3.24). At lower dose than free naringin, effective cytoprotection of 1:50 micelles against ethanol-induced ulcer in rat model has been indicated by significant reduction in mucosal damage, gastr...Continue Reading

Citations

Nov 10, 2018·Journal of Medicinal Food·Cleber da Silveira TorresHaydee Maria Moreira
Mar 13, 2019·Frontiers in Chemistry·Wei-Jie WangTzong-Rong Ger
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jun ZhangBi-Wei Song
Feb 29, 2020·Drug Design, Development and Therapy·Eman Ebrahim El NaggarMohammed Fawzy Hamed
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Catarina SerafimLeônia Batista
Mar 7, 2021·Pharmaceutics·Mohammed BhiaMehdi Shakibaei
Apr 16, 2021·Frontiers in Pharmacology·Maryam Ghanbari-MovahedAnupam Bishayee
Sep 30, 2021·Journal of Agricultural and Food Chemistry·Peiyuan LiGuangning Kou

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