PMID: 26328441Sep 4, 2015Paper

Polymeric Nanocapsules and Lipid-Core Nanocapsules Have Diverse Skin Penetration

Journal of Nanoscience and Nanotechnology
Tainá L de BrumAdriana Raffin Pohlmann

Abstract

Biodegradable nanoparticles have been widely studied as drug carriers in order to increase drug solubility in aqueous media, modify biodistribution, target tissues and organs or control the drug release. Those nanoparticles are, in general, produced as liquid formulations to act as final dosage forms or as intermediate for solid or semi-solid products. Considering the dermatological applications, as medicines or cosmetics, different nanoparticles have been proposed to control the skin penetration of encapsulated lipophilic substances. A point rarely investigated is the penetration of the carrier itself into the skin, independent of the drug penetration profile. In this way, our objective was to correlate the flexibility of the biodegradable nanoparticles to the depth of their skin penetration. To minimize the impact of the chemical composition, the surface chemistry or the shape and size distribution on the results, two kinds of polymeric nanocapsules presenting diverse mechanical properties were produced using almost the same materials and their concentrations. The nanocapsules (NC) and the lipid-core nanocapsules (LNC) were prepared by solvent displacement using Rhodamine B-labeled polymer, oil and surfactants. The only diffe...Continue Reading

Citations

Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·C MathesU F Schaefer
Mar 31, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lucas Almeida RigoRuy Carlos Ruver Beck
Feb 23, 2019·Expert Opinion on Drug Delivery·Ana Cláudia SantosAntónio Ribeiro
Jan 27, 2021·International Journal of Pharmaceutics·Ricardo LorenzoniSilvia Stanisçuaski Guterres
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vivian S K NishihiraRodrigo A Vaucher
Dec 10, 2019·Journal of Natural Products·Janaína B SeibertOrlando D H Dos Santos

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