Polymeric Nanocarriers for Non-Viral Gene Delivery

Journal of Biomedical Nanotechnology
Ling LiChangyang Gong

Abstract

Gene therapy holds great promise for the treatment of acquired and inherited diseases. Non-viral gene delivery systems are gaining recognition as alternatives to viral gene vectors due to their safety and low immunogenicity. The effective delivery of nucleic acids requires overcoming many biological barriers that would otherwise hinder transfection efficiency. Developing safe and efficient vectors that can overcome these obstacles is at the heart of current gene delivery research. Polymeric nanocarriers, such as polyethylenimine (PEI), poly(L-lysine) (PLL), poly[2-(dimethylamino) ethyl methacrylate] (PDMAEMA), polyamidoamine (PAMAM), chitosan and poly(amino-co-ester)s (PAEs), play an important role in gene delivery. In this review, we first describe the current understanding of the biological barriers to non-viral gene delivery and recent progress in addressing these barriers. Several of the most widely used non-viral polymeric nanocarriers are discussed, and detailed strategies that have accumulated from nearly two decades of research aimed at overcoming biological barriers and improving gene transfer are highlighted.

Citations

Jul 16, 2015·Human Gene Therapy·Ling LiYu-Quan Wei
Aug 28, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Sara PalchettiGiulio Caracciolo
Dec 3, 2016·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Yoav HadasLior Zangi
Apr 1, 2017·Applied Microbiology and Biotechnology·Faez Iqbal KhanMd Imtaiyaz Hassan
Mar 31, 2017·PloS One·Shirley O'DeaFitz-Roy Curry
Dec 22, 2015·Chemical Communications : Chem Comm·Jianbing LiuZhen Xi
Jan 29, 2016·Biomaterials Science·Santiago GrijalvoDavid Díaz Díaz
Jun 22, 2018·Molecular Diagnosis & Therapy·Fang LiuFei Wang
Jul 6, 2019·Journal of Biomedical Materials Research. Part a·Gyeong Jin Lee, Tae-Il Kim
Dec 5, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Fengqian ChenQi Liu
Dec 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jia-Ying YanShu-Yi Lin
Nov 12, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Alexandru ChivuWenhui Song
Nov 17, 2016·Colloids and Surfaces. B, Biointerfaces·Fatemeh SheikhsaranAli Dehshahri
Apr 14, 2021·ACS Applied Materials & Interfaces·Jie ZhouHonglin Jin
Jun 1, 2021·Biochimica Et Biophysica Acta. General Subjects·Md RizwanullahJaved Ahmad
Jun 25, 2021·Advanced Healthcare Materials·Marcelo Calderón, Sarah Hedtrich
Aug 8, 2021·International Journal of Molecular Sciences·Daniel KeimRuth Freitag
Aug 15, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiuhua PanXiaole Qi

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