Polymeric nano/microcapsules of liquid perfluorocarbons for ultrasonic imaging: physical characterization

Langmuir : the ACS Journal of Surfaces and Colloids
Emilia PisaniElias Fattal

Abstract

Ultrasonic imaging is a widely available, noninvasive, and cost-effective diagnostic modality, but vessels smaller than 200 mum in diameter are impossible to visualize. Commercial ultrasound contrast agents (UCAs), consisting of encapsulated gas microbubbles injected intravenously, enable only a qualitative visualization of the microvascularization for a short period of time since they are rather unstable. In a strategy to develop more stable UCAs, we designed a process to obtain nano/microcapsules with a single core of liquid perfluorocarbons within a biodegradable polymeric shell of homogeneous thickness. The polymer shell should improve the stability of the capsules as compared to UCAs stabilized by a monomolecular layer, while the acoustic impedance of the perfluorocarbons should ensure their echogenicity. These capsules have been optimized to encapsulate several liquid perfluorocarbons: perfluorohexane, perfluorodecalin, and perfluorooctyl bromide. The system is rather versatile: the mean size of the capsules can be adjusted between 70 nm and 25 microm and the thickness-to-radius ratio (T/R) can be easily modulated by simply modifying the polymer-to-perfluorocarbon ratio. T/R does not depend on the size of the capsules and...Continue Reading

References

Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J KostR Langer
Sep 1, 1968·Investigative Radiology·R Gramiak, P M Shah
Nov 20, 1998·Journal of Colloid and Interface Science·A Loxley, B Vincent
Feb 9, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Jon N MarshGregory M Lanza
Aug 22, 2002·Academic Radiology·Samuel A WicklineGregory M Lanza
Aug 30, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie A StraubHoward Bernstein

❮ Previous
Next ❯

Citations

Nov 11, 2009·Pharmaceutical Research·Raquel Díaz-LópezElias Fattal
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexander L Klibanov
Aug 9, 2008·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Zhan-Wen XingJi-Bin Liu
Mar 17, 2010·Chemical Reviews·Angelique Louie
Oct 27, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ivan GorelikovNaomi Matsuura
Jun 4, 2010·Journal of the Royal Society, Interface·Ming-Wei ChangMohan Edirisinghe
Dec 15, 2010·Journal of Biomaterials Science. Polymer Edition·Xiaoyan XiongYiyao Liu
Dec 13, 2012·The Journal of the Acoustical Society of America·François CoulouvratWladimir Urbach
Mar 25, 2011·The Journal of the Acoustical Society of America·Guillaume HaïatWladimir Urbach
Mar 15, 2014·Soft Matter·Tiantian KongHo Cheung Shum
Mar 13, 2014·The Journal of the Acoustical Society of America·Matthieu GuédraJean-Louis Thomas
Apr 23, 2014·Nature Communications·Guillaume LajoinieMichel Versluis
Dec 18, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Odile DiouNicolas Tsapis
Sep 30, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Ana Rita C DuarteKlavs F Jensen
Oct 30, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Takaichi WatanabeTsutomu Ono
Oct 16, 2013·Journal of Microencapsulation·Claudia StephanChristian Mayer
Jun 27, 2009·Drug Development and Industrial Pharmacy·Kunn Hadinoto, Wean Sin Cheow
Jan 22, 2009·Journal of Pharmaceutical Sciences·Tsong-Long HwangJia-You Fang
Nov 23, 2011·Journal of Pharmaceutical Sciences·Nathalie Ferreira Silva De MeloLeonardo Fernandes Fraceto
Jun 26, 2012·Advanced Drug Delivery Reviews·Simona Mura, Patrick Couvreur
Jan 3, 2016·The Journal of the Acoustical Society of America·Matthieu Guédra, François Coulouvrat
May 19, 2009·International Journal of Pharmaceutics·Kunn Hadinoto
Mar 21, 2007·International Journal of Pharmaceutics·Zohra ManaAlf Lamprecht
Oct 26, 2011·Contrast Media & Molecular Imaging·Ronald X Xu
Jul 11, 2012·Small·Yi ZhaoDaniel Crespy
Sep 16, 2010·NMR in Biomedicine·Jesús Ruiz-CabelloJeff W M Bulte
Apr 8, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Céline GiraudeauJulien Valette
Sep 15, 2015·Physical Chemistry Chemical Physics : PCCP·Ksenia AstafyevaNicolas Taulier
Apr 9, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Baptiste SarrazinPatrick Guenoun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.