PMID: 2482440Oct 1, 1989Paper

[Polymerization of DNA fragments coding epitopes of the surface antigen of hepatitis B in Escherichia coli cells].

Molekuliarnaia genetika, mikrobiologiia i virusologiia
O V SergienkoT I Tikhonenko

Abstract

Synthetic oligonucleotides coding for the amino acid residues 135-151 (A, B) and 93-109 (C) of the hepatitis B surface antigen (HBsAg) have been polymerized. The obtained polymers (AC)n and (BCAC)n were inserted into the beginning of the lacZ gene under the control of the chloramphenicol promoter or the right promoter PR of bacteriophage lambda. Stability of the obtained plasmids was investigated during transformation, cell growth and gene expression.

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