PMID: 8460127Mar 15, 1993Paper

Polymerization of murine macrophage inflammatory protein 1 alpha inactivates its myelosuppressive effects in vitro: the active form is a monomer

Proceedings of the National Academy of Sciences of the United States of America
C MantelH E Broxmeyer

Abstract

Macrophage inflammatory protein (MIP) 1 alpha has myelosuppressive and myeloprotective activity. That MIP-1 alpha polymerizes is known; this phenomenon was evaluated in terms of myelosuppression by assessing the effects of recombinant murine MIP-1 alpha on colony formation of murine and human myeloid progenitor cells in vitro. The following results are reported: (i) Polymerization is diluent- and concentration-dependent. (ii) Monomeric MIP-1 alpha is the active suppressive form for myeloid progenitor cells in vitro. (iii) Polymerized MIP-1 alpha is inactive and does not interfere with suppression by monomeric MIP-1 alpha. (iv) MIP-1 alpha has approximately 1000-fold higher specific activity than has been reported, but its effects are still specific for immature subsets of myeloid progenitors. (v) Suppression is initiated during the DNA-synthesis phase of the cell cycle. We conclude that polymerization of MIP-1 alpha might be a control mechanism that limits the myelosuppressive effects of monomeric MIP-1 alpha.

References

Oct 1, 1978·The Journal of Experimental Medicine·H E BroxmeyerM de Sousa
Jan 1, 1992·The American Journal of Pediatric Hematology/oncology·H E Broxmeyer
May 1, 1991·Cytokine·T J Schall
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jan 1, 1988·Critical Reviews in Oncology/hematology·H E Broxmeyer, D E Williams
Jul 16, 1981·Biochemical and Biophysical Research Communications·R M BennettJ Davis

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Citations

Jun 29, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·J ThierryJ Wdzieczak-Bakala
Sep 4, 2001·International Journal of Hematology·H E Broxmeyer
Feb 24, 1999·Experimental Hematology·G L GilmoreR K Shadduck
Sep 11, 2003·Journal of Hematotherapy & Stem Cell Research·Mark H KaplanHal E Broxmeyer
May 29, 2007·Molecular and Cellular Biology·Hal E BroxmeyerAlexander L Dent
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
Dec 22, 1999·The Journal of Clinical Investigation·C H KimH E Broxmeyer
Apr 3, 2001·Journal of Neuroimmunology·W Pan, A J Kastin
Jun 19, 2004·Transplant Immunology·Jong Kwon ParkRichard V Perez
Jan 9, 1998·Baillière's Clinical Haematology·G J Graham
Feb 11, 2005·Blood·Christian A WysockiJonathan S Serody

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