Polymerized albumin binding to serum in various liver diseases: its significance and relation to hepatitis B virus infection

Journal of Gastroenterology and Hepatology
S DashN C Nayak

Abstract

Sensitive and specific enzyme-linked immunosorbent assays (ELISA) were developed to detect separately the binding of polymerized human serum albumin (PHSA) to its antibody (A-PHSA) and to the hepatitis B surface antigen (HBsAg). A-PHSA was not detected in normal serum, whereas more than one-third to about half of sera from patients with acute liver cell injury showed this antibody. Frequency of A-PHSA positivity was low in chronic liver diseases, being relatively higher in those with continuing liver injury. A-PHSA detection was not related to seropositivity for HBsAg. PHSA binding of HBsAg positive sera showed a higher frequency of positivity in chronic carriers than acute hepatitis B. Of 172 asymptomatic HBsAg carriers, PHSA binding was demonstrated in 25 (15%), the frequency being significantly high if HBeAg was also present (84%). Binding was infrequent in sera having anti-HBe (2.9%) and in those negative for both HBeAg and anti-HBe (2.7%). Binding of HBsAg to PHSA was significantly higher than to human serum albumin (HSA). Immunoblotting of separated HBsAg components showed PHSA binding specifically to the high molecular weight peptide. PHSA binding in HBsAg positive serum may indicate the latter's infectivity as detected ...Continue Reading

References

May 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H OkamotoT Nakamura
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W M LeeR M Galbraith
Feb 1, 1986·Seminars in Liver Disease·J L Dienstag, H J Alter
Mar 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T L WrightR A Weisiger
Jan 1, 1986·Current Topics in Pathology. Ergebnisse Der Pathologie
Oct 1, 1971·Biochimica Et Biophysica Acta·D Gambal
Mar 5, 1981·Nature·J SkellyA J Zuckerman
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TrevisanL Bianchi
Jun 1, 1981·Infection and Immunity·S N Thung, M A Gerber

❮ Previous
Next ❯

Citations

Jan 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S DashS K Panda
Mar 1, 1992·The Australian and New Zealand Journal of Psychiatry·S L Einfeld
Jan 1, 1993·Journal of Community Health Nursing·R Laferriere
Jan 1, 1991·Critical Reviews in Biochemistry and Molecular Biology·A K BejR M Atlas
Oct 1, 1995·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B SallenC Mabilat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.