PMID: 3772998Oct 1, 1986Paper

Polymerized pyridoxylated hemoglobin: efficacy as an O2 carrier

The Journal of Trauma
Steven A GouldG S Moss

Abstract

We have prepared a polymerized pyridoxylated hemoglobin solution (Poly SFH-P) with a normal [Hb] of 14 gm/dl and a normal COP of 20 torr. Although this normal [Hb] is a significant improvement over prior products, the P50 of 16-20 torr raises a concern about the ability of Poly SFH-P to effectively transport O2 in the presence of red cells with their normal P50 of 26 torr. This study quantitatively assessed the contribution of Poly SFH-P to total O2 delivery and consumption in the clinically relevant range of hematocrits. The results document that Poly SFH-P supports life at zero hematocrit, and makes significant contributions to total O2 delivery and consumption in the presence of red cells. Poly SFH-P permits a higher plasma [Hb], and has a longer intravascular persistence than any unpolymerized hemoglobin solution. Poly SFH-P is thus an effective O2 carrier, and offers greater potential than prior products as a clinically useful red cell substitute.

Citations

Oct 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·E P ViazovaM G Vashkevich
Aug 31, 2000·Critical Care Medicine·J CreteurJ L Vincent
Jan 16, 2004·Critical Care Medicine·Jacques Creteur, Jean-Louis Vincent
Nov 30, 1991·BMJ : British Medical Journal·S J Urbaniak
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Jun 13, 1998·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·C ConoverR G Shorr
Jan 1, 1987·Biomaterials, Artificial Cells, and Artificial Organs·G S MossH L Sehgal
Jan 1, 1994·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·N CedratiC Vigneron
Feb 21, 2009·Journal of the American College of Surgeons·Ernest E MooreUNKNOWN PolyHeme Study Group
Dec 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S K SwanR J Przybelski
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Nov 9, 2005·Biochemistry·Nikolai Gourianov, Ronald Kluger
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