Polymers for viral gene delivery

Expert Opinion on Drug Delivery
Chun Wang, Phuong-Truc Pham

Abstract

The development of viral vectors capable of providing efficient gene transfer in diseased tissues without causing any pathogenic effects is pivotal for overcoming the many challenges facing gene therapy. Immune responses against viral vectors, inadequate gene expression and inefficient targeting to specific cells in vivo are some of the major problems limiting the clinical utility of viral gene therapy. This review will focus on recent progress in strategic polymer-based modifications to improve the performance and biocompatibility of a variety of viral vectors. We will discuss the preclinical development of four approaches involving injectable polymers, polyelectrolytes, polymer microspheres and polymer-virus conjugates. Much progress has been made in creating 'hybrid' gene delivery vectors that combine the strengths of polymers and viruses. With further optimization, these hybrid vectors, which may be safer and more effective, are likely to succeed in clinical applications.

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Citations

Dec 21, 2010·International Journal of Nanomedicine·Sanyuan Hu, Yangde Zhang
Jan 8, 2014·Expert Opinion on Drug Delivery·Dayananda KasalaChae-Ok Yun
Dec 26, 2015·Journal of Materials Science. Materials in Medicine·Qingxia GuanYongji Li
Dec 23, 2008·Trends in Molecular Medicine·Te-Lang Wu, Hildegund C J Ertl
Apr 10, 2019·Polymers·Ana Rey-Rico, Magali Cucchiarini
Nov 17, 2020·Advanced Healthcare Materials·Yi WangDavid R Nisbet
Feb 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dayananda KasalaChae-Ok Yun
Feb 2, 2019·Bioconjugate Chemistry·Douglas Steinhauff, Hamidreza Ghandehari

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