Polymersomes Eradicating Intracellular Bacteria.

ACS Nano
Federico FenaroliLoris Rizzello

Abstract

Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favoring chronic and/or disseminated infection. One of the most infamous is the bacteria that cause tuberculosis (TB), which is the most pandemic and one of the deadliest diseases, with one-third of the world's population infected and an average of 1.8 million deaths/year worldwide. Here we demonstrate the effective targeting and intracellular delivery of antibiotics to infected macrophages both in vitro and in vivo, using pH-sensitive nanoscopic polymersomes made of PMPC-PDPA block copolymer. Polymersomes showed the ability to significantly enhance the efficacy of the antibiotics killing Mycobacterium bovis, Mycobacterium tuberculosis, and another established intracellular pathogen, Staphylococcus aureus. Moreover, they demonstrated to easily access TB-like granuloma tissues-one of the harshest environments to penetrate-in zebrafish models. We thus successfully exploited this targeting for the effective eradication of several intracellular bacteria, includ...Continue Reading

References

May 15, 1999·Science·B M DischerD A Hammer
Mar 22, 2002·Nature Reviews. Immunology·S H Kaufmann
Nov 26, 2002·Nature Cell Biology·Jonathan C Kagan, Craig R Roy
Aug 17, 2005·Traffic·Isabel C Morrow, Robert G Parton
Aug 24, 2006·Blood·Stephen A RenshawMoira K B Whyte
Jun 19, 2007·The Journal of Biological Chemistry·Stuart Marshall-ClarkePaul Rothwell
Jul 5, 2007·Nature Reviews. Molecular Cell Biology·Satyajit Mayor, Richard E Pagano
Dec 18, 2007·Nature Cell Biology·Sudha Kumari, Satyajit Mayor
Feb 27, 2008·Cellular Microbiology·David M Tobin, Lalita Ramakrishnan
Apr 17, 2009·Nature Reviews. Microbiology·Katrina RayChristoph M Tang
Jan 12, 2012·Nature Reviews. Molecular Cell Biology·Shawn M Ferguson, Pietro De Camilli
Jan 14, 2012·Annals of the New York Academy of Sciences·Giuseppe ValacchiAlessandra Pecorelli
Apr 21, 2012·Nature Reviews. Immunology·Lalita Ramakrishnan
Oct 2, 2012·Circulation Research·Sonika SaddarPhilip W Shaul
Oct 2, 2012·Angewandte Chemie·Linge WangGiuseppe Battaglia
Feb 4, 2014·Nature Reviews. Microbiology·Véronique Dartois
May 24, 2014·Metabolism: Clinical and Experimental·Wen-Jun ShenSalman Azhar
May 24, 2014·Nature Reviews. Immunology·Florent Ginhoux, Steffen Jung
Oct 13, 2014·Current Opinion in Pharmacology·Léa MessagerGiuseppe Battaglia
Dec 4, 2014·Nature·Stefan H OehlersDavid M Tobin
Dec 18, 2014·Immunity·Jordan V Price, Russell E Vance
Dec 20, 2014·Cell·C J CambierLalita Ramakrishnan
Sep 4, 2015·Nanomedicine·Lijuan GuanGiuseppe Battaglia
Jun 9, 2016·Scientific Reports·James D RobertsonGiuseppe Battaglia
Sep 15, 2016·ACS Infectious Diseases·Jansy P SarathyVéronique Dartois
Oct 4, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher T DeeAdam F L Hurlstone
Oct 14, 2016·Journal of Leukocyte Biology·Reinhild FeuersteinPhilipp Henneke
Mar 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·James D RobertsonStephen A Renshaw
Apr 25, 2017·Nature Nanotechnology·Min LuoJinming Gao
Dec 9, 2017·International Journal of Medical Microbiology : IJMM·Jessica HornMartin Fraunholz
May 29, 2018·Journal of Internal Medicine·C LangeT Schön

❮ Previous
Next ❯

Citations

Mar 19, 2021·Nanoscale·Jinyu RongSijie Lin
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria MercadanteAlessandro Poma
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui Liu, Alessandro Poma
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lia Queiroz do Amaral
Apr 6, 2021·Critical Reviews in Microbiology·Avijit GoswamiRachit Agarwal
Sep 1, 2021·Advanced Drug Delivery Reviews·Santhni SubramaniamClive A Prestidge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.