Polymethoxyflavonoids tangeretin and nobiletin increase glucose uptake in murine adipocytes

Phytotherapy Research : PTR
Kenji OndaToshihiko Hirano

Abstract

Tangeretin and nobiletin are polymethoxyflavonoids that are contained in citrus fruits. Polymethoxyflavonoids are reported to have several biological functions including anti-inflammatory, anti-atherogenic, or anti-diabetic effects. However, whether polymethoxyflavonoids directly affect glucose uptake in tissues is not well understood. In the current study, we investigated whether tangeretin and nobiletin affect glucose uptake in insulin target cells such as adipocytes. We observed that treatment with tangeretin or nobiletin significantly increased the uptake of [(3) H]-deoxyglucose in differentiated 3T3-F442A adipocytes in a concentration-dependent manner. Data showed that phosphatidyl inositol 3 kinase, Akt1/2, and the protein kinase A pathways were involved in the increase in glucose uptake induced by polymethoxyflavonoids. These data suggest that the anti-diabetic action of polymethoxyflavonoids is partly exerted via these signaling pathways in insulin target tissues.

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Citations

Jul 3, 2013·Phytotherapy Research : PTR·Xiuying MaLiming Zhou
Oct 21, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hao HuangLonghuo Wu
Mar 24, 2018·Journal of Food and Drug Analysis·Wei-Lun HungLucy Sun Hwang
Mar 10, 2020·Oxidative Medicine and Cellular Longevity·Jeremiah Oshiomame Unuofin, Sogolo Lucky Lebelo
May 28, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mahdi Vajdi, Mahdieh Abbasalizad Farhangi
Sep 10, 2021·Critical Reviews in Food Science and Nutrition·Rizliya Visvanathan, Gary Williamson

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