Polymicrobial antibiofilm activity of the membranotropic peptide gH625 and its analogue

Microbial Pathogenesis
E de AlteriisE Galdiero

Abstract

This work illustrates a new role for the membranotropic peptide gH625 and its derivative gH625-GCGKKK in impairing formation of polymicrobial biofilms. Mixed biofilms composed of Candida and bacterial species cause frequently infections and failure of medical silicone devices and also show a major drug resistance than single-species biofilms. Inhibition and eradication of biofilms were evaluated by complementary methods: XTT-reduction, and crystal violet staining (CV). Our results indicate that gH625-GCGKKKK, better than the native peptide, strongly inhibited formation of mixed biofilms of clinical isolates of C. tropicalis/S. marcescens and C. tropicalis/S. aureus and reduced the biofilm architecture, interfering with cell adhesion and polymeric matrix, as well as eradicated the long-term polymicrobial biofilms on silicone surface.

Citations

Nov 20, 2019·International Journal of Molecular Sciences·Tomislav RončevićAlessandro Tossi
Aug 1, 2020·Frontiers in Cellular and Infection Microbiology·Derry K MercerAlfredo M Angeles-Boza
Dec 22, 2019·Journal of Fungi·Maria Elisa RodriguesCélia F Rodrigues
Jul 13, 2019·Pharmaceutics·Emilia GaldieroRosa Carotenuto
Aug 31, 2019·Future Microbiology·José Jc SidrimDébora de Scm Castelo-Branco
Apr 3, 2020·Scientific Reports·Emilia GaldieroStefania Galdiero
Jan 21, 2021·Pharmaceutics·Annarita FalangaStefania Galdiero
Jan 10, 2021·International Journal of Molecular Sciences·Giovanna BatoniSemih Esin
Jan 25, 2020·Biochimie·Sathishkumar MunusamyCarlos Munoz-Garay
Mar 7, 2021·Microorganisms·Katrien Van DyckPatrick Van Dijck
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Harinash RaoPei Pei Chong
Apr 4, 2021·International Journal of Molecular Sciences·Emilia GaldieroMarco Guida
May 19, 2021·Critical Reviews in Microbiology·Fazlurrahman KhanYoung-Mog Kim
Aug 8, 2021·International Journal of Molecular Sciences·Ana C AfonsoManuel Simões

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